Back to Search
Start Over
Improvement of extrathymic T cell type of large granular lymphocyte (LGL) leukemia by cyclosporin A: the serum level of Fas ligand is a marker of LGL leukemia activity
- Source :
- European journal of haematology. 65(4)
- Publication Year :
- 2000
-
Abstract
- We report a case of gammadelta T-cell-type large granular lymphocyte (LGL) leukemia (CD3 +,CD8 +, CD57 +,TCR gammadelta+), which was accompanied by pure red cell aplasia, neutropenia and thrombocytosis. Southern blotting analysis of the T-cell receptor beta gene showed the germline configuration, but clonal TCR J gamma rearrangements were identified. These granular lymphocytes demonstrated non-major histocompatibility complex-restricted cytotoxicitity. The serum-soluble FasL (sFasL) concentration of this patient was very high, whereas the serum levels of tumor necrosis factor alpha (TNF-alpha), interferon gamma (IFN-gamma), interleukin-1 beta (IL-1beta), interleukin-2 (IL-2) and thrombopoietin were normal. After treatment with cyclosporin A, anemia and thrombocytosis were improved, and LGL and the elevated sFasL concentration decreased. These observations suggested that FasL may have played a role in the establishment of the clinical symptoms of this patient and could be useful as an indicator of disease activity.
- Subjects :
- Male
Leukemia, T-Cell
CD3 Complex
CD3
T cell
chemical and pharmacologic phenomena
Red-Cell Aplasia, Pure
Immunophenotyping
Cyclosporin a
Medicine
Humans
Interferon gamma
fas Receptor
Thrombopoietin
Thrombocytosis
biology
business.industry
T-cell receptor
hemic and immune systems
Receptors, Antigen, T-Cell, gamma-delta
Hematology
General Medicine
Middle Aged
medicine.disease
Leukemia, Lymphoid
Leukemia
medicine.anatomical_structure
Treatment Outcome
Immunology
Cancer research
biology.protein
Cyclosporine
business
CD8
medicine.drug
Subjects
Details
- ISSN :
- 09024441
- Volume :
- 65
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- European journal of haematology
- Accession number :
- edsair.doi.dedup.....92ae21d08c570880ae51c8be8d79210b