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Prospective study on early virologic response to treatment with interferon α-2b plus ribavirin in patients with chronic hepatitis C genotype 1b
- Source :
- Hepatology Research. 33:285-291
- Publication Year :
- 2005
- Publisher :
- Elsevier BV, 2005.
-
Abstract
- To evaluate the predictive value of early virologic response (EVR) of achieving a sustained virologic response (SVR), an open, prospective trial including 42 patients with chronic hepatitis C genotype 1b was performed with directly observed 24-week treatment with interferon α-2b plus ribavirin. We assessed the predictive values of EVR at days 3, 7, 14, and weeks 4, 8, and 12 of the SVR. The SVR in an intention-to-treat analysis was 19.0%. Patients who reached SVR presented a significantly faster reduction in plasma viral load. Stepwise multiple logistic regression analysis of the factors (gender, age, IFN dosage, ribavirin dosage, HCV RNA, ISDR, and loss of HCV RNA at week 4) revealed that loss of HCV RNA at week 4 was the only independent variable of treatment outcome (P = 0.0039). A viral load at treatment day 3 above 100 kIU/ml, at day 7 above 50 kIU/ml, and at day 14 above 10 kIU/ml was 100% predictive for virologic non-response in all except 1 patient. The cutoff levels for HCV RNA at days 3 and 14 of treatment were associated with an algorithm of the failure to detect HCV RNA after 12 weeks of treatment. In conclusions, a very early virologic response assessment could be useful for prediction of later outcome of combination therapy in chronic hepatitis C genotype 1b.
- Subjects :
- medicine.medical_specialty
Hepatology
Combination therapy
business.industry
Ribavirin
Hepatitis C virus
virus diseases
medicine.disease_cause
Gastroenterology
digestive system diseases
chemistry.chemical_compound
Infectious Diseases
chemistry
Chronic hepatitis
Genotype 1b
Interferon
Internal medicine
Immunology
medicine
business
Prospective cohort study
Viral load
medicine.drug
Subjects
Details
- ISSN :
- 13866346
- Volume :
- 33
- Database :
- OpenAIRE
- Journal :
- Hepatology Research
- Accession number :
- edsair.doi.dedup.....92a8e5989d4d8665cb82a94cfdac0511