Phosphatidic acid phosphatase 1 impairs SARS-CoV-2 replication by affecting the glycerophospholipid metabolism pathway

Authors :: Bingpeng Yan
Shuofeng Yuan
Jianli Cao
Kingchun Fung
Pok-Man Lai
Feifei Yin
Kong-Hung Sze
Zhenzhi Qin
Yubin Xie
Zi-Wei Ye
Terrence Tsz-Tai Yuen
Kenn Ka-Heng Chik
Jessica Oi-Ling Tsang
Zijiao Zou
Chris Chun-Yiu Chan
Cuiting Luo
Jian-Piao Cai
Kwok-Hung Chan
Tom Wai-Hing Chung
Anthony Raymond Tam
Hin Chu
Dong-Yan Jin
Ivan Fan-Ngai Hung
Kwok-Yung Yuen
Richard Yi-Tsun Kao
Jasper Fuk-Woo Chan
Source :: International Journal of Biological Sciences. 18:4744-4755
Publication Year :: 2022
Publisher :: Ivyspring International Publisher, 2022.
Abstract: Viruses exploit the host lipid metabolism machinery to achieve efficient replication. We herein characterize the lipids profile reprogramming

Subjects :: SARS-CoV-2
Phosphatidylethanolamines
Phosphatidate Phosphatase
COVID-19
Glycerophospholipids
Cell Biology
Ceramides
Lipid Metabolism
Applied Microbiology and Biotechnology
Phosphatidylcholines
Humans
Caco-2 Cells
Molecular Biology
Ecology, Evolution, Behavior and Systematics
Ethers
Developmental Biology

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