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13C-aminopyrine demethylation is decreased in cirrhotic patients with normal biochemical markers
- Source :
- Isotopes in Environmental and Health Studies. 49:346-356
- Publication Year :
- 2013
- Publisher :
- Informa UK Limited, 2013.
-
Abstract
- This study determined the rates of (13)C-aminopyrine metabolism in patients with varying degrees of liver cirrhosis as defined by clinical scores. Twenty-five cirrhotic patients and 18 healthy subjects underwent a (13)C-aminopyrine breath test. The cumulative per cent dose recovery (cPDR) of (13)C on breath expressed as a percentage of the administered dose at 2 h was significantly lower in cirrhotic patients than in healthy subjects (median: 1.7% versus 9.0%; p
- Subjects :
- Adult
Liver Cirrhosis
Male
medicine.medical_specialty
Cirrhosis
Bilirubin
Methylation
Gastroenterology
Inorganic Chemistry
Young Adult
chemistry.chemical_compound
Liver disease
Liver Function Tests
Internal medicine
medicine
Humans
Environmental Chemistry
Young adult
Aminopyrine
Finland
General Environmental Science
Demethylation
Breath test
Carbon Isotopes
medicine.diagnostic_test
business.industry
Middle Aged
medicine.disease
Breath Tests
chemistry
Alkaline phosphatase
Female
business
Liver function tests
Biomarkers
Subjects
Details
- ISSN :
- 14772639 and 10256016
- Volume :
- 49
- Database :
- OpenAIRE
- Journal :
- Isotopes in Environmental and Health Studies
- Accession number :
- edsair.doi.dedup.....92a08aef368936bf0daa546eab35edfa