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New sulfa drug derivatives and their zinc(II) complexes: synthesis, spectroscopic properties and in vitro cytotoxic activities

Authors :
Hakan Şahal
Samet Öz
Tuba Keskin
Suat Tekin
Erdal Canpolat
Mehmet Kaya
Publication Year :
2023
Publisher :
Taylor & Francis, 2023.

Abstract

Synthesis of four sulfa drug derivatives (L1–L4) and Zn(II) complexes derived from sulfonamide group antibiotic substances was carried out using the hydrothermal technique (HT) and their structures of the obtained compounds were explained using elemental analysis (EA), FT-IR and NMR (1H- and 13C-). Cytotoxic activities of four novel sulfa drug based-Schiff base compounds and their Zn(II) complexes were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay using MCF-7 (human breast cancer), Caco-2 (human colorectal adenocarcinoma), A2780 (human ovarian cancer) and LNCaP (human prostate adenocarcinoma) cell lines. LogIC50 values of all obtained compounds were computed with the Graphpad Prism 6 program after 24 h of treatment for MCF-7, Caco-2, A2780 and LNCaP cells. Comet assay experiments were performed using LogIC50 concentrations of all compounds to determine DNA damage. Based on the data obtained, all compounds significantly decreased MCF-7, Caco-2, A2780 and LNCaP cell viability compared to the control groups (p < 0.05). Communicated by Ramaswamy H. Sarma

Details

Database :
OpenAIRE
Accession number :
edsair.doi.dedup.....929ef5b3ddce8a69f22664d6cdb0491a
Full Text :
https://doi.org/10.6084/m9.figshare.22347537