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The Significance of VDR Genetic Polymorphisms in the Etiology of Preeclampsia in Pregnant Polish Women
- Source :
- Diagnostics, Vol 11, Iss 1698, p 1698 (2021), Diagnostics, Volume 11, Issue 9
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- For the first time in the Polish population, we aimed to investigate associations between the VDR gene single-nucleotide polymorphisms (SNPs) BsmI (rs15444410), ApaI (rs7975232), FokI (rs19735810), and TaqI (rs731236) and the development of preeclampsia (PE). A case–control study surveyed 122 preeclamptic and 184 normotensive pregnant women. The polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) method was performed to examine the maternal VDR FokI, BsmI, TaqI, and ApaI polymorphisms. The VDR BsmIAA homozygous genotype was statistically significantly more frequent in preeclamptic women compared to the control group (p = 0.0263), which was also associated with a 2-fold increased risk of PE (OR = 2.06, p = 0.012). A correlation between the VDR BsmI polymorphism with systolic and diastolic blood hypertension was noted. Furthermore, 3-marker haplotype CTA (TaqI/ApaI/BsmI) was associated with significantly higher systolic (p = 0.0075) and diastolic (p = 0.0072) blood pressure. Association and haplotype analysis indicated that the VDR BsmI A allele could play a significant role in the PE pathomechanism and hence could be a risk factor for PE development in pregnant Polish women. These results indicate the importance of the VDR BsmI polymorphism and reveal that this variant is closely associated with a higher predisposition to hypertension.
- Subjects :
- medicine.medical_specialty
Medicine (General)
biology
TaqI
molecular biology methods
business.industry
Clinical Biochemistry
Haplotype
Single-nucleotide polymorphism
medicine.disease
Calcitriol receptor
FokI
Preeclampsia
preeclampsia
chemistry.chemical_compound
Endocrinology
R5-920
chemistry
Polymorphism (computer science)
Internal medicine
VDR genetic polymorphisms
biology.protein
Medicine
Risk factor
business
Subjects
Details
- Language :
- English
- ISSN :
- 20754418
- Volume :
- 11
- Issue :
- 1698
- Database :
- OpenAIRE
- Journal :
- Diagnostics
- Accession number :
- edsair.doi.dedup.....929418f4007f0a2cca66977c4cac45ea