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Intratumoral T cell subset ratios and Fas ligand expression on brain tumor endothelium
- Source :
- Journal of Neuro-oncology. 64:55-61
- Publication Year :
- 2003
- Publisher :
- Springer Science and Business Media LLC, 2003.
-
Abstract
- Introduction: T cell presence in TIL, and the ratio of CD8+ and CD4+ T cell subsets in particular, can correlate with tumor prognosis in some tumors, although the significance of such infiltration into glioma is controversial. However, gliomas represent a lower extreme in their extent of T cell infiltration, and are thus useful in assessing factors that can decrease T cell presence within tumor tissue. Fas ligand, a pro-apoptotic cell surface protein, may play a key role in reduction of T cells in tumor tissue. Objective: To assess the level of FasL expression on brain tumor endothelium and to correlate this with relative levels of CD4+ and CD8+ T cell subsets in TIL from brain tumors. Methods: CD3+, CD4+, and CD8+ cells were quantified in fresh TIL by flow cytometry. Paraffin embedded sections of tumors, including meningiomas and gliomas as well as extracranial malignancies, underwent immunohistochemical staining for FasL and Von-Willebrand’s factor (Factor VIII) to determine expression levels of endothelial FasL. Results: FasL expression was high in aggressive intracranial malignancies compared to more indolent neoplasms, and correlated inversely with CD8+/CD4+ TIL ratios in all tumor classes combined (ANOVA,p
- Subjects :
- Cancer Research
Pathology
medicine.medical_specialty
Fas Ligand Protein
CD30
T cell
CD4-CD8 Ratio
chemical and pharmacologic phenomena
Biology
Fas ligand
Interleukin 21
Lymphocytes, Tumor-Infiltrating
T-Lymphocyte Subsets
Glioma
medicine
Humans
Cytotoxic T cell
Endothelium
Antigen-presenting cell
Membrane Glycoproteins
Brain Neoplasms
Brain
hemic and immune systems
medicine.disease
medicine.anatomical_structure
Neurology
Oncology
Disease Progression
Cancer research
Neurology (clinical)
CD8
Subjects
Details
- ISSN :
- 15737373 and 0167594X
- Volume :
- 64
- Database :
- OpenAIRE
- Journal :
- Journal of Neuro-oncology
- Accession number :
- edsair.doi.dedup.....928fc12fcf69f0892700f1796acd505e
- Full Text :
- https://doi.org/10.1007/bf02700020