Strength training protects against prostate injury in alcoholic rats

Made available in DSpace on 2021-06-25T10:46:44Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-05-01 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Alcoholic injury can alter the hormonal signaling pathway and lead to glucose and lipid metabolism disorders. In this study, we investigated whether the strength training could exert protective effects against the alterations caused by ethanol consumption on prostatic metabolism. A UChB, ethanol-preferring rats were used in this study. Strength training was conducted for 3 days per week for 13 weeks, rats performed jumps in water carrying a weight load strapped to their chests as part of a strength training protocol. The reduced alcohol consumption by strength training was accompanied by increased glucose, serum lipid profile, total protein levels, and reduced hormonal levels. The results of protein expression of prostatic tissues in the ethanol- and strength training-treated groups indicated that “steroidal hormone receptors,” “fatty acid translocation,” and “cell regulation” were significantly different between ethanol- and strength training-treated groups. Taken together, these findings show that strength training effectively ameliorated prostatic injuries in alcoholic rats at least partially by acting on lipids receptors and steroidal hormone receptors pathway, suggesting the strength training as a potential novel therapeutic strategy for treating prostate injuries caused by ethanol. Department of Physical Education School of Technology and Sciences UNESP Campus of Presidente Prudente Postgraduate Program in Multicentric Physiological Sciences São Paulo State University—UNESP Campus of Aracatuba Postgraduate Program in Movement Sciences São Paulo State University—UNESP Campus of Presidente Prudente Department of Anatomy Institute of Biosciences São Paulo State University UNESP Postgraduate Program in Animal Science Postgraduate Program in Health Sciences University of Western São Paulo—UNOESTE Department of Plant Agriculture University of Guelph Department of Structural and Functional Biology Institute of Biology State University of Campina—UNICAMP State University of Western Paraná Department of Veterinary Hygiene and Public Health Faculty of Veterinary Medicine and Animal Science São Paulo State University UNESP Department of Physical Education School of Technology and Sciences UNESP Campus of Presidente Prudente Postgraduate Program in Multicentric Physiological Sciences São Paulo State University—UNESP Campus of Aracatuba Postgraduate Program in Movement Sciences São Paulo State University—UNESP Campus of Presidente Prudente Department of Anatomy Institute of Biosciences São Paulo State University UNESP Department of Veterinary Hygiene and Public Health Faculty of Veterinary Medicine and Animal Science São Paulo State University UNESP CAPES: 001 FAPESP: 08/00479-6 FAPESP: 13/25927-0