Back to Search
Start Over
Defining heterogeneity within bacterial populations via single cell approaches
- Source :
- BioEssays. 38:782-790
- Publication Year :
- 2016
- Publisher :
- Wiley, 2016.
-
Abstract
- Bacterial populations are heterogeneous, which in many cases can provide a selective advantage during changes in environmental conditions. In some instances, heterogeneity exists at the genetic level, in which significant allelic variation occurs within a population seeded by a single cell. In other cases, heterogeneity exists due to phenotypic differences within a clonal, genetically identical population. A variety of mechanisms can drive this latter strategy. Stochastic fluctuations can drive differential gene expression, but heterogeneity in gene expression can also be driven by environmental changes sensed by individual cells residing in distinct locales. Utilizing multiple single cell approaches, workers have started to uncover the extent of heterogeneity within bacterial populations. This review will first describe several examples of phenotypic and genetic heterogeneity, and then discuss many single cell approaches that have recently been applied to define heterogeneity within bacterial populations.
- Subjects :
- 0301 basic medicine
030106 microbiology
Population
Cell
Environment
Biology
Bacterial Physiological Phenomena
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
Single-cell analysis
Genetic variation
medicine
Animals
Humans
Allele
education
Genetics
education.field_of_study
Bacteria
Genetic heterogeneity
Genetic Variation
food and beverages
Gene Expression Regulation, Bacterial
Adaptation, Physiological
Phenotype
Clone Cells
030104 developmental biology
medicine.anatomical_structure
Evolutionary biology
Host-Pathogen Interactions
Single-Cell Analysis
Subjects
Details
- ISSN :
- 02659247
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- BioEssays
- Accession number :
- edsair.doi.dedup.....928745af1af4d3698213995f61950162