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Neurological Outcome According to the Site of Cannulation in Septic Children Supported by Venoarterial Extracorporeal Membrane Oxygenation
- Source :
- ASAIO Journal. 67:1349-1355
- Publication Year :
- 2021
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2021.
-
Abstract
- The impact of cervical cannulation on neurologic outcome has not been yet studied among children receiving venoarterial extracorporeal membrane oxygenation (VA-ECMO) in the context of severe sepsis or septic shock. A retrospective cohort study was performed using the extracorporeal life support organization (ELSO) registry. A total of 559 children weighing less than 20 kg with a primary or secondary diagnosis of severe sepsis, septic shock or toxic shock syndrome were included between January 1, 2010, and December 31, 2019. Cervical cannulation was performed in 485 children (87%) and central cannulation in 74 children (13%). The prevalence of acute neurologic event (ANE) was 32%, including clinical and/or electroencephalographic seizures, cerebral infarction, cerebral hemorrhage, and/or brain death. In multivariable analysis, we did not find an association between cervical cannulation and greater/lesser odds of ANE during ECMO (adjusted odds ratio [aOR] = 1.39, 95% confidence interval [CI] 0.72-2.65; P = 0.326). Only pre-ECMO acidosis was independently associated with the development of ANE (pH < 6.99; aOR = 2.71, 95% CI 1.34-5.49; P = 0.006; pH 6.99 to
- Subjects :
- medicine.medical_treatment
Population
Biomedical Engineering
Biophysics
Bioengineering
Context (language use)
Extracorporeal
Catheterization
Biomaterials
Extracorporeal Membrane Oxygenation
Sepsis
medicine
Extracorporeal membrane oxygenation
Humans
Child
education
Retrospective Studies
education.field_of_study
Septic shock
business.industry
Cerebral infarction
Retrospective cohort study
General Medicine
Odds ratio
medicine.disease
Shock, Septic
Anesthesia
business
Subjects
Details
- ISSN :
- 10582916
- Volume :
- 67
- Database :
- OpenAIRE
- Journal :
- ASAIO Journal
- Accession number :
- edsair.doi.dedup.....928484c385eadea95495fb6a8b8f393b
- Full Text :
- https://doi.org/10.1097/mat.0000000000001532