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Antimicrobial Activity of Amino-Derivatized Cationic Polysaccharides
- Source :
- Indian Journal of Microbiology. 59:96-99
- Publication Year :
- 2018
- Publisher :
- Springer Science and Business Media LLC, 2018.
-
Abstract
- To improve the antimicrobial property of chitosan, water-soluble chitosan modified in their quaternary ammonium groups were synthesized. The antimicrobial properties were evaluated against Escherichia coli, Bacillus subtilis, Saccharomyces cerevisiae and Candida tropicalis. The activities increased with increasing cationic charges and the length of the alkyl chain as follows amino-chitosan, dimethylaminoethyl-chitosan, dimethylpropyl amino-chitosan, dimethylamino-1-propyl-chitosan, diethylaminoethyl (DEAE)-chitosan, and quaternized DEAE-chitosan. The modified cationic chitosans showed high antimicrobial property against B. subtilis—Gram-positive bacteria, but were less active towards yeast (C. tropicalis and S. cerevisiae) and E. coli—Gram-negative bacteria. The simple structure of the Gram-positive bacteria may explain why the cationic chitosan derivatives are more active towards B. subtilis than yeast and E. coli. The target sites of the chitosan derivatives are assumed to be the cytoplasmic membranes of microorganisms. The antimicrobial activities were strongly dependent on the cationic charge and the molecular weight. It can be suggested that these cationic chitosan derivatives have potential as antimicrobial agents. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s12088-018-0764-7) contains supplementary material, which is available to authorized users.
- Subjects :
- 0106 biological sciences
0303 health sciences
Gram-negative bacteria
biology
030306 microbiology
Short Communications
technology, industry, and agriculture
Cationic polymerization
macromolecular substances
Bacillus subtilis
equipment and supplies
biology.organism_classification
Antimicrobial
01 natural sciences
Microbiology
Combinatorial chemistry
Yeast
carbohydrates (lipids)
Candida tropicalis
Chitosan
03 medical and health sciences
chemistry.chemical_compound
chemistry
010608 biotechnology
Bacteria
Subjects
Details
- ISSN :
- 09737715 and 00468991
- Volume :
- 59
- Database :
- OpenAIRE
- Journal :
- Indian Journal of Microbiology
- Accession number :
- edsair.doi.dedup.....928042125fddb701fc1af082dcbc343c