Back to Search
Start Over
Associations of polymorphisms in CTLA-4 and IL-18 with liver diseases: evidence from a meta-analysis
- Source :
- Bioscience reports.
- Publication Year :
- 2019
-
Abstract
- Background Associations between polymorphisms in cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) / interleukin-18 (IL-18) and susceptibility to liver diseases were already reported by many publications. The aim of this meta-analysis was to clarify associations between polymorphisms in CTLA-4/IL-18 and liver diseases by combing the results of all relevant publications. Methods Eligible publications were searched from Pubmed, Embase, WOS and CNKI. The latest literature searching update was performed on 2nd October, 2019. We used Review Manager to combine the results of individual studies. Results Sixty-seven studies were included in this study. Combined results revealed that CTLA-4 rs231775 (dominant comparison: OR 0.83, 95 % CI 0.79-0.88; recessive comparison: OR 1.33, 95 % CI 1.23-1.43; allele comparison: OR 0.84, 95 % CI 0.78-0.90), IL-18 rs1946518 (dominant comparison: OR 0.85, 95 % CI 0.78-0.92; recessive comparison: OR 1.29, 95 % CI 1.13-1.48; allele comparison: OR 0.79, 95 % CI 0.71-0.88) and IL-18 rs187238 (dominant comparison: OR 1.28, 95 % CI 1.07-1.53; over-dominant comparison: OR 0.81, 95 % CI 0.68-0.97; allele comparison: OR 1.22, 95 % CI 1.07-1.39) polymorphisms were all significantly associated with liver diseases in the general population. We also obtained similar significant associations for CTLA-4 rs231775, CTLA-4 rs5742909, CTLA-4 rs3087243, IL-18 rs1946518 and IL-18 rs187238 polymorphisms in subgroup analyses. Conclusions Collectively, this meta-analysis proved that CTLA-4 rs231775, CTLA-4 rs5742909, CTLA-4 rs3087243, IL-18 rs1946518 and IL-18 rs187238 polymorphisms may confer susceptibility to various types of liver diseases.
- Subjects :
- 0301 basic medicine
education.field_of_study
business.industry
Population
Biophysics
Review manager
Cell Biology
Biochemistry
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
Antigen
CTLA-4
030220 oncology & carcinogenesis
Meta-analysis
Immunology
Cytotoxic T cell
Medicine
Interleukin 18
Allele
education
business
Molecular Biology
Subjects
Details
- ISSN :
- 15734935
- Database :
- OpenAIRE
- Journal :
- Bioscience reports
- Accession number :
- edsair.doi.dedup.....926c19fb68e8fb825187ae972255a2b4