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Convulsive status epilepticus in a quaternary hospital paediatric intensive care unit (PICU) in South Africa: An 8 year review

Authors :
Yavini Reddy
Lawrence Mubaiwa
Yusentha Balakrishna
Source :
Seizure. 51:55-60
Publication Year :
2017
Publisher :
Elsevier BV, 2017.

Abstract

Purpose Convulsive status epilepticus (CSE) is associated with a high morbidity and mortality. This study aimed to describe the clinical profile, aetiology, neuroimaging and EEG findings as well as outcome of children with CSE in Sub-Saharan Africa. Methods This was a retrospective analysis of electronic records of children with CSE admitted to the Paediatric Intensive Care Unit (PICU) over an 8-year period from January 2007 to December 2014. Results Seventy six patients were admitted to the PICU with CSE and 55(72%) had refractory status epilepticus. The median age at presentation was 15 months (IQR 6–37 months). The main aetiologies were meningoencephalitis and gastroenteritis in 33(43%) and 19(25%) patients respectively. The most frequently used antiepileptic drugs for CSE in PICU consisted of infusions of midazolam (96%) and thiopentone (22%). Neuroimaging findings were abnormal in 53(75%) patients with hypoxic changes in 17 patients. On multivariable regression, the predictors of poor outcome included the use of more than 3 antiepileptic drugs in PICU(RR-1.41(1.12–1.78), p=0.003), duration of mechanical ventilation for more than 3days (RR 1.98(1.22–3.20), p=0.005) and abnormal neuroimaging findings (RR 3.21(1.53–6.72), p=0.002). The mortality rate was 24%(n=18). Persistent seizures or a new neurological deficit occurred in 58%(n=44). The main cause of mortality was CSE related diffuse cortical and brainstem injury. Predominant neurological sequelae were cerebral palsy and persistent epilepsy. Conclusion The high burden of infection related CSE is associated with high morbidity and mortality rates in contrast to the rates in developed countries. This highlights the need for early recognition and treatment of underlying conditions.

Details

ISSN :
10591311
Volume :
51
Database :
OpenAIRE
Journal :
Seizure
Accession number :
edsair.doi.dedup.....926c02c6557a2612cd552178c25184ac
Full Text :
https://doi.org/10.1016/j.seizure.2017.07.016