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Characterization of polymeric nanoparticles for treatment of partial injury to the central nervous system
- Source :
- Data in Brief, Data in Brief, Vol 7, Iss, Pp 152-156 (2016)
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Before using nanoparticles for therapeutic applications, it is necessary to comprehensively investigate nanoparticle effects, both in vitro and in vivo. In the associated research article [1] we generate multimodal polymeric nanoparticles functionalized with an antibody, that are designed to deliver an anti-oxidant to astrocytes. Here we provide additional data demonstrating the effects of the nanoparticle preparations on an indicator of oxidative stress in an immortalized Müller cell line in vitro. We provide data demonstrating the use of nanoscale secondary ion mass spectroscopy (NanoSIMS) to identify specific ions in bulk dried NP. NanoSIMS is also used to visualize 40Ca microdomains in the z dimension of optic nerve that has been subjected to a partial optic nerve transection. The associated article [1] describes the use of NanoSIMS to quantify 40Ca microdomains in optic nerve from animals treated with various nanoparticle preparations and provides further interpretation and discussion of the findings.
- Subjects :
- Multidisciplinary
Chemistry
Central nervous system
Nanoparticle
Nanotechnology
02 engineering and technology
lcsh:Computer applications to medicine. Medical informatics
010402 general chemistry
021001 nanoscience & nanotechnology
Polymeric nanoparticles
01 natural sciences
In vitro
0104 chemical sciences
Characterization (materials science)
Secondary Ion Mass Spectroscopy
medicine.anatomical_structure
In vivo
medicine
Biophysics
Optic nerve
lcsh:R858-859.7
lcsh:Science (General)
0210 nano-technology
lcsh:Q1-390
Data Article
Subjects
Details
- ISSN :
- 23523409
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Data in Brief
- Accession number :
- edsair.doi.dedup.....926bf229e34ec7e462a3392823c7b8ec
- Full Text :
- https://doi.org/10.1016/j.dib.2016.02.019