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Additive prognostic value of carbohydrate antigen‐125 over frailty in patients undergoing transcatheter aortic valve replacement
- Source :
- Catheterization and Cardiovascular Interventions. 97
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- BACKGROUND To evaluate the additive prognostic value of myocardial, inflammatory, and renal biomarkers according to frailty status in patients undergoing transcatheter aortic valve replacement (TAVR) for aortic stenosis (AS). METHODS A total of 111 subjects who underwent TAVR at Hospital Italiano de Buenos Aires, Argentina between January 2016 and December 2018 were retrospectively reviewed. Plasma levels of N-terminal pro-B-type natriuretic peptide (NT-proBNP), high sensitivity troponin T (hs-cTnT), C-reactive protein (CRP), cystatin-c (Cys-C) and carbohydrate antigen-125 (CA-125) were assessed prior to TAVR. Frailty status was assessed according to the fried physical frailty phenotype (FPFP). The primary endpoint was defined as all-cause death and/or readmission for worsening congestive heart failure (CHF) within the first year after TAVR. RESULTS Of the 111 patients included, 48/111 (43%) were considered to be "frail" according to the FPFP. Among biomarkers, we found CA-125 to be strongly associated with the primary endpoint (p = .006). CA-125 ≥ 18.2 U/ml was present in 41% and was associated with a higher rate of the primary endpoint (31% vs. 9%; p = .003). After multivariable adjustment, CA-125 ≥ 18.2 U/ml (hazard ratio [HR] 3.17; p = .024) was the only independent predictor of the primary endpoint. Finally, the inclusion of CA-125 to frailty significantly improved C-index (0.68-0.74; p
- Subjects :
- medicine.medical_specialty
Time Factors
medicine.drug_class
medicine.medical_treatment
Carbohydrates
030204 cardiovascular system & hematology
Risk Assessment
Transcatheter Aortic Valve Replacement
03 medical and health sciences
0302 clinical medicine
Valve replacement
Risk Factors
Internal medicine
medicine
Natriuretic peptide
Clinical endpoint
Humans
Radiology, Nuclear Medicine and imaging
Prospective Studies
030212 general & internal medicine
Retrospective Studies
Frailty
business.industry
Hazard ratio
Aortic Valve Stenosis
General Medicine
Prognosis
medicine.disease
Stenosis
Treatment Outcome
Aortic Valve
Aortic valve stenosis
Heart failure
Cardiology
Biomarker (medicine)
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 1522726X and 15221946
- Volume :
- 97
- Database :
- OpenAIRE
- Journal :
- Catheterization and Cardiovascular Interventions
- Accession number :
- edsair.doi.dedup.....9266961819ffd0ff7be9c1948bfa5701