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Multiple Functions of MSCA-1/TNAP in Adult Mesenchymal Progenitor/Stromal Cells
- Source :
- Stem Cells International, Stem Cells International, Hindawi Publishing Corporation, 2016, pp.ID 1815982, Stem Cells International, Vol 2016 (2016)
- Publication Year :
- 2015
-
Abstract
- International audience; Our knowledge about mesenchymal stem cells has considerably grown in the last years. Since the proof of concept of the existence of such cells in the 70s by Friedenstein et al., a growing mass of reports were conducted for a better definition of these cells and for the reevaluation from the term “mesenchymal stem cells” to the term “mesenchymal stromal cells (MSCs).” Being more than a semantic shift, concepts behind this new terminology reveal the complexity and the heterogeneity of the cells grouped in MSC family especially as these cells are present in nearly all adult tissues. Recently, mesenchymal stromal cell antigen-1 (MSCA-1)/tissue nonspecific alkaline phosphatase (TNAP) was described as a new cell surface marker of MSCs from different tissues. The alkaline phosphatase activity of this protein could be involved in wide range of MSC features described below from cell differentiation to immunomodulatory properties, as well as occurrence of pathologies. The present review aims to decipher and summarize the role of TNAP in progenitor cells from different tissues focusing preferentially on brain, bone marrow, and adipose tissue.
- Subjects :
- 0301 basic medicine
lcsh:Internal medicine
Stromal cell
business.industry
[CHIM.ORGA]Chemical Sciences/Organic chemistry
Cellular differentiation
Mesenchymal stem cell
Clinical uses of mesenchymal stem cells
Cell Biology
Review Article
Bioinformatics
Cell biology
03 medical and health sciences
030104 developmental biology
medicine.anatomical_structure
medicine
Alkaline phosphatase
Bone marrow
Progenitor cell
[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM]
lcsh:RC31-1245
business
Molecular Biology
Stem cell transplantation for articular cartilage repair
Subjects
Details
- ISSN :
- 1687966X and 16879678
- Volume :
- 2016
- Database :
- OpenAIRE
- Journal :
- Stem cells international
- Accession number :
- edsair.doi.dedup.....9262a35e3263a651cdcc7fd4425f8d09