Bioactive constituents from the stems of Dalbergia parviflora

From the stems of Dalbergia parviflora , three known flavonoids, six known isoflavonoids, a new isoflavone, dalparvone ( 2 ) and a new cinnamyl derivative, dalparvinene ( 6 ) were isolated and characterized. Isoflavan 3 exhibited strong cytotoxicity against KB and NCI-H187 cell lines with IC 50 values of 0.53 and 2.04 μg/ml, respectively. Compound 6 demonstrated strong cytotoxicity against NCI-H187 with an IC 50 value of 1.46 μg/ml. Compounds 4 and 6 possessed moderate cytotoxicity against KB cells with IC 50 values of 6.78 and 9.89 μg/ml, respectively. In addition, 2 exhibited moderate antiplasmodial activity with an IC 50 value of 8.19 μg/ml.