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ABO blood group is a predictor of survival in patients with laryngeal cancer
- Source :
- Chinese Journal of Cancer, Vol 35, Iss 1, Pp 1-7 (2016), Chinese Journal of Cancer
- Publication Year :
- 2016
- Publisher :
- BMC, 2016.
-
Abstract
- Background Whether the ABO blood group is associated with the survival of patients with laryngeal cancer remains unknown. The purpose of this study was to investigate the association between the ABO blood group and clinicopathologic characteristics of patients with laryngeal cancer and assess whether the ABO blood group was associated with prognosis. Methods We analyzed the records of 1260 patients with laryngeal cancer who underwent curative treatment at Sun Yat-sen University Cancer Center between January 1993 and December 2009. The Chi-square test was used to assess the relationship between the ABO blood group and clinicopathologic characteristics. The Kaplan–Meier method was used to estimate 3-, 5-, and 10-year overall survival (OS) rates. The Cox proportional hazards model was used in univariate and multivariate analyses of OS. Results No significant association was found between the ABO blood group and clinicopathologic characteristics except for primary tumor site. The median OS for patients with blood groups A, B, AB, and O were 87.0, 80.0, 90.0, and 72.5 months, respectively. The 3-, 5-, and 10-year OS rates were 82.4%, 76.0%, and 67.5% for patients with blood group A; 77.4%, 69.8%, and 58.4% for patients with blood group B; 82.2%, 73.1%, and 65.6% for patients with blood group AB; and 71.7%, 66.4%, and 55.5% for patients with blood group O, respectively. Univariate and multivariate analyses showed that the ABO blood group had significant effects on prognosis in patients with laryngeal cancer. Conclusions The ABO blood group is associated with survival in patients with laryngeal cancer. Patients with blood group O had significantly shorter OS than patients with other ABO blood groups.
- Subjects :
- 0301 basic medicine
Adult
Male
medicine.medical_specialty
Multivariate analysis
Survival
Gastroenterology
lcsh:RC254-282
ABO Blood-Group System
03 medical and health sciences
Young Adult
0302 clinical medicine
Laryngeal cancer
Internal medicine
ABO blood group system
Correspondence
parasitic diseases
medicine
Overall survival
Biomarkers, Tumor
Humans
In patient
The ABO blood group
Laryngeal Neoplasms
Aged
Neoplasm Staging
Retrospective Studies
Immune Evasion
Aged, 80 and over
Proportional hazards model
business.industry
Cancer
Middle Aged
medicine.disease
Prognosis
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Primary tumor
Combined Modality Therapy
Surgery
Survival Rate
030104 developmental biology
Oncology
Curative treatment
030220 oncology & carcinogenesis
Female
Original Article
business
Follow-Up Studies
Subjects
Details
- Language :
- English
- Volume :
- 35
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Chinese Journal of Cancer
- Accession number :
- edsair.doi.dedup.....92421a37e24afc9167e1b5938c7223d0