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Isolation and cholinesterase activity of Amaryllidaceae alkaloids from Nerine bowdenii
- Source :
- ResearcherID, Scopus-Elsevier
- Publication Year :
- 2012
-
Abstract
- Amaryllidaceae species are known as ornamental plants. Some contain galanthamine, an acetylcholinesterase inhibitor. The chemical composition of the alkaloid extract of bulbs of Nerine bowdenii Watson has been analyzed by means of GC/MS. Twenty-two compounds were detected and nineteen of them identified, one of which was belladine. The alkaloid extract showed promising cholinesterase inhibitory activities against human blood acetylcholinesterase (HuAChE; IC50= 87.9±3.5 μg/mL) and human plasma butyrylcholinesterase (HuBuChE; IC50 = 14.8±1.1 μg/mL). Belladine inhibited HuAChE and HuBuChE in a dose-dependent manner with IC50 values of 781±12.5 μM and 284.8±4.2 μM, respectively.
- Subjects :
- medicine.drug_class
Plant Science
Gas Chromatography-Mass Spectrometry
chemistry.chemical_compound
Alkaloids
Drug Discovery
Nerine bowdenii
medicine
Liliaceae
Humans
Amaryllidaceae Alkaloids
Butyrylcholinesterase
Cholinesterase
Pharmacology
biology
Traditional medicine
Dose-Response Relationship, Drug
Plant Extracts
Alkaloid
General Medicine
Amaryllidaceae
biology.organism_classification
Acetylcholinesterase
Complementary and alternative medicine
chemistry
Acetylcholinesterase inhibitor
biology.protein
Cholinesterase Inhibitors
Subjects
Details
- ISSN :
- 1934578X
- Volume :
- 6
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Natural product communications
- Accession number :
- edsair.doi.dedup.....923e61cd48b06375609a99f686a80d9a