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Initiation of hepatic stellate cell activation extends into chronic liver disease
- Source :
- Cell Death and Disease, Vol 12, Iss 12, Pp 1-10 (2021), Cell Death & Disease
- Publication Year :
- 2021
- Publisher :
- Nature Publishing Group, 2021.
-
Abstract
- Activated hepatic stellate cells (aHSC) are the main source of extra cellular matrix in liver fibrosis. Activation is classically divided in two phases: initiation and perpetuation. Currently, HSC-based therapeutic candidates largely focus on targeting the aHSCs in the perpetuation phase. However, the importance of HSC initiation during chronic liver disease (CLD) remains unclear. Here, we identified transcriptional programs of initiating and activated HSCs by RNA sequencing, using in vitro and in vivo mouse models of fibrosis. Importantly, we show that both programs are active in HSCs during murine and human CLD. In human cirrhotic livers, scar associated mesenchymal cells employ both transcriptional programs at the single cell level. Our results indicate that the transcriptional programs that drive the initiation of HSCs are still active in humans suffering from CLD. We conclude that molecules involved in the initiation of HSC activation, or in the maintenance of aHSCs can be considered equally important in the search for druggable targets of chronic liver disease. ispartof: CELL DEATH & DISEASE vol:12 issue:12 ispartof: location:England status: published
- Subjects :
- Male
Cancer Research
extra cellular matrix
Immunology
Biology
Chronic liver disease
Article
Extracellular matrix
Mice
Cellular and Molecular Neuroscience
In vivo
Fibrosis
Hepatic Stellate Cells
medicine
FIBROSIS
Animals
Humans
Activated hepatic stellate cells
liver fibrosis
Science & Technology
QH573-671
Liver Diseases
Mesenchymal stem cell
chronic liver disease
Cell Biology
medicine.disease
Hepatic stellate cell activation
In vitro
Disease Models, Animal
Mechanisms of disease
Chronic Disease
Hepatic stellate cell
Cancer research
Cytology
Life Sciences & Biomedicine
Subjects
Details
- Language :
- English
- ISSN :
- 20414889
- Volume :
- 12
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Cell Death and Disease
- Accession number :
- edsair.doi.dedup.....922aa3d718553c5051ca021cc8b3040b