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Implication of human drug transporters to toxicokinetics and toxicity of pesticides
- Source :
- Pest Management Science, Pest Management Science, Wiley, 2020, 76 (1), pp.18-25. ⟨10.1002/ps.5577⟩, Pest Management Science, 2020, 76 (1), pp.18-25. ⟨10.1002/ps.5577⟩
- Publication Year :
- 2020
- Publisher :
- HAL CCSD, 2020.
-
Abstract
- Human membrane drug transporters are recognized as major actors of pharmacokinetics. Pesticides also interact with human drug transporters, which may have consequences for pesticide toxicokinetics and toxicity. The present review summarizes key findings about this topic. In vitro assays have demonstrated that some pesticides, belonging to various chemical classes, modulate drug transporter activity, regulate transporter expression and/or are substrates, thus bringing the proof of concept for pesticide-transporter relationships. The expected low human concentration of pesticides in response to environmental exposure constitutes a key-parameter to be kept in mind for judging the in vivo relevance of such pesticide-transporter interactions and their consequences for human health. Existing data about interactions of pesticides with drug transporters remain, however, rather sparse; more extensive and systematic characterization of pesticide-transporter relationships, through the use of high throughput in vitro assays and/or in silico methods, is, therefore, required. In addition, consideration of transporter polymorphisms, pesticide mixture effects and physiological and pathological factors governing drug transporter expression may help to better define the in vivo relevance of pesticide-transporter interactions in terms of toxicokinetics and toxicity for humans. © 2019 Society of Chemical Industry.
- Subjects :
- Drug
media_common.quotation_subject
In silico
Drug transporter activity
Computational biology
Biology
phytosanitaire
030226 pharmacology & pharmacy
Intestinal absorption
phytosanitary
03 medical and health sciences
0302 clinical medicine
Humans
Toxicokinetics
toxicité
Computer Simulation
human
Pesticides
pesticide
030304 developmental biology
media_common
0303 health sciences
In vitro toxicology
Membrane Transport Proteins
toxicity
toxicologie
Transporter
Environmental Exposure
General Medicine
Environmental exposure
toxicokinetic
toxicocinétique
Insect Science
[SDV.TOX]Life Sciences [q-bio]/Toxicology
humain
Agronomy and Crop Science
toxicology
Subjects
Details
- Language :
- English
- ISSN :
- 1526498X and 15264998
- Database :
- OpenAIRE
- Journal :
- Pest Management Science, Pest Management Science, Wiley, 2020, 76 (1), pp.18-25. ⟨10.1002/ps.5577⟩, Pest Management Science, 2020, 76 (1), pp.18-25. ⟨10.1002/ps.5577⟩
- Accession number :
- edsair.doi.dedup.....9227b2a49281c0003facaa636c0591f4