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Synthesis and Properties of C-Azalyxonucleosides
- Source :
- The Journal of organic chemistry. 63(21)
- Publication Year :
- 2001
-
Abstract
- 1-beta-(4-Imidazoyl)- and 1-beta-(5-uracilyl)-1,4-dideoxy-1,4-imino-L-lyxitols were synthesized stereoselectively via a sequential procedure by the addition of the corresponding metal salts of heterocycles, Swern oxidation, reductive aminocyclization, and deprotection. Their structures were determined based on X-ray crystallography. From the NMR measurements of their N-acyl derivatives, two rotational isomers were observed. Their bioassay is also described.
- Subjects :
- Metal salts
Chemistry
Organic Chemistry
Swern oxidation
Bioassay
Organic chemistry
Subjects
Details
- ISSN :
- 15206904
- Volume :
- 63
- Issue :
- 21
- Database :
- OpenAIRE
- Journal :
- The Journal of organic chemistry
- Accession number :
- edsair.doi.dedup.....921de1c505e5bfa2c2e65a72348ef355