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A self-reinforcing biodegradable implant made of poly(ɛ-caprolactone)/calcium phosphate ceramic composite for craniomaxillofacial fracture fixation
- Source :
- Journal of Cranio-Maxillofacial Surgery. 44:1333-1341
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Purpose Biodegradable polymer fixators have been used widely in oral and maxillofacial surgery for fracture management. However, short-comings such as insufficient mechanical strength, inappropriate degradation time, lack of radiolucency, and foreign body reactions during bone remodeling remain. Material and methods In this study, calcium phosphate ceramic (CPC, including tricalcium phosphate [TCP] and tetracalcium phosphate/dicalcium phosphate [TTCP/DCP]) and poly(e-caprolactone) (PCL) were used to fabricate biodegradable orthopedic fixation devices. Results Different weight ratios of CPC were added to PCL, and the results showed that the PCL/CPC composites had good radiopacity, mechanical properties, and biocompatibility. CPC was transformed into hydroxyapatite when the composites were immersed in simulated body fluid. The PCL/TTCP/DCP composite had a higher compressive strength relative to PCL/TCP after setting, and this self-reinforcing property contributed to the hydration of TTCP/DCP and formation of apatite crystals. Thus, PCL/TTCP/DCP screws were prepared for animal studies. No postoperative mortality or complications were noted 6 months postsurgery. Biodegradation of the PCL/TTCP/DCP screws and newly formed bony tissue around the degraded composites were shown on both micro–computed tomography and histology. No peri-implant bone resorption was noted. Conclusion The self-reinforcing PCL/TTCP/DCP composite can be used to fabricate biodegradable fixators for fracture management in craniomaxillofacial fracture fixation.
- Subjects :
- Calcium Phosphates
Compressive Strength
Biocompatibility
Surface Properties
Polyesters
Radiodensity
Simulated body fluid
Bone Screws
0206 medical engineering
Biocompatible Materials
macromolecular substances
02 engineering and technology
Osseointegration
Mice
chemistry.chemical_compound
X-Ray Diffraction
Absorbable Implants
Materials Testing
Fracture fixation
Animals
Medicine
Femur
Skull Fractures
business.industry
technology, industry, and agriculture
Tetracalcium phosphate
ttcp
Hydrogen-Ion Concentration
musculoskeletal system
equipment and supplies
021001 nanoscience & nanotechnology
020601 biomedical engineering
Biodegradable polymer
Disease Models, Animal
Otorhinolaryngology
chemistry
Microscopy, Electron, Scanning
Surgery
Rabbits
Oral Surgery
0210 nano-technology
business
Biomedical engineering
Subjects
Details
- ISSN :
- 10105182
- Volume :
- 44
- Database :
- OpenAIRE
- Journal :
- Journal of Cranio-Maxillofacial Surgery
- Accession number :
- edsair.doi.dedup.....921ca2037fc479a027c52b2800a7c138