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Neural Response to Social Exclusion Moderates the Link Between Adolescent Anxiety Symptoms and Substance Use
- Source :
- Biol Psychiatry Cogn Neurosci Neuroimaging, Biological psychiatry. Cognitive neuroscience and neuroimaging, vol 7, iss 2
- Publication Year :
- 2022
- Publisher :
- Elsevier BV, 2022.
-
Abstract
- Background Substance use (SU) typically increases from middle to late adolescence. Anxiety is one factor associated with greater SU, although variability in who uses substances remains. Some models suggest that brain-based susceptibility markers could reveal which adolescents are at a higher risk for psychopathology, but it is unknown whether these individual differences attenuate or accentuate the association between anxiety and elevated SU even if normative. This study addressed this gap by testing whether neural response to social exclusion moderates the association between anxiety symptoms and increased SU from middle to late adolescence. Methods Participants were 181 Mexican-origin adolescents (48% female; 16–17 years old) who completed a social exclusion task during a functional magnetic resonance imaging scan and filled out questionnaires about their SU and anxiety symptoms. Analyses focused on neural response to social exclusion versus inclusion within 3 regions of interest and change in SU across 2 years. Results Dorsal anterior cingulate cortex response to social exclusion, but not subgenual anterior cingulate cortex or anterior insula, moderated the relation between anxiety symptoms and SU, such that higher anxiety symptoms predicted a greater relative increase in SU only for those youth with a lower dorsal anterior cingulate cortex response to exclusion. Conclusions Blunted dorsal anterior cingulate cortex response to social exclusion may serve as a neural susceptibility marker of altered conflict monitoring or emotion regulation in middle adolescence that, in combination with high levels of anxious feelings, elevates the risk for onset of and/or increased SU by late adolescence. These findings have implications for designing targeted interventions to mitigate SU among adolescents.
- Subjects :
- Male
Substance use
Anxiety
Peers
Substance Misuse
0302 clinical medicine
Adolescent brain
media_common
Pediatric
medicine.diagnostic_test
05 social sciences
Brain
Anxiety Disorders
Mental Health
medicine.anatomical_structure
Social Isolation
Feeling
Female
medicine.symptom
Clinical psychology
Psychopathology
Social exclusion
Adolescent
Substance-Related Disorders
Cognitive Neuroscience
media_common.quotation_subject
Stress
Gyrus Cinguli
Article
050105 experimental psychology
03 medical and health sciences
Clinical Research
Behavioral and Social Science
medicine
Humans
0501 psychology and cognitive sciences
Radiology, Nuclear Medicine and imaging
Association (psychology)
Biological Psychiatry
Anterior cingulate cortex
business.industry
Neurosciences
Brain Disorders
Good Health and Well Being
Normative
Neurology (clinical)
Functional magnetic resonance imaging
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 24519022
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
- Accession number :
- edsair.doi.dedup.....921034c266c3f057d704f7788089ce59