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Understanding the roles of N6-methyladenosine writers, readers and erasers in breast cancer
- Source :
- Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 6, Pp 551-560 (2021)
- Publication Year :
- 2021
- Publisher :
- Elsevier, 2021.
-
Abstract
- Breast cancer is believed to be driven by epigenetic regulation of genes implicated in cell proliferation, survival, and differentiation. Recently, aberrant N6-methyladenosine (m6A) decorations turned up as crucial epigenetic regulator for malignant breast cancer, which may serve as new targets for breast cancer treatment. Here we briefly outline the functions of m6A and its regulatory proteins, including m6A "writers," "readers," and "erasers" on RNA life fate, recapitulate the latest breakthroughs in understanding m6A modification and its regulatory proteins, and the underlying molecular mechanisms that contribute to the carcinogenesis and the progression of breast cancer, so as to provide potential epigenetic targets for diagnosis, treatment and prognosis in breast cancer.
- Subjects :
- 0301 basic medicine
Cancer Research
Methyltransferase
Demethylase
Regulator
medicine.disease_cause
03 medical and health sciences
chemistry.chemical_compound
m6A modification
0302 clinical medicine
Breast cancer
medicine
Epigenetics
skin and connective tissue diseases
Gene
m6A reader
RC254-282
biology
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.disease
030104 developmental biology
chemistry
030220 oncology & carcinogenesis
biology.protein
Cancer research
N6-Methyladenosine
Carcinogenesis
Subjects
Details
- Language :
- English
- ISSN :
- 14765586
- Volume :
- 23
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Neoplasia: An International Journal for Oncology Research
- Accession number :
- edsair.doi.dedup.....920e2bffcfadb08fd5248dc1ad7c355d