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The Effect of Pioglitazone on Nitric Oxide Synthase in Patients With Type 2 Diabetes Mellitus
- Source :
- Journal of the CardioMetabolic Syndrome. 3:200-204
- Publication Year :
- 2008
- Publisher :
- Wiley, 2008.
-
Abstract
- The aim of this study was to evaluate the effect of pioglitazone on nitric oxide in patients with type 2 diabetes and coronary artery disease. Twenty-seven patients with coronary artery disease and diabetes mellitus who had received coronary stenting were eligible for the study. They were assigned to the no insulin resistance (NIR) group, the insulin resistance (IR) group, and the pioglitazone group (30 mg once a day). Endothelial nitric oxide synthase (eNOS), inducible nitric oxide synthase (iNOS), tumor necrosis factor alpha (TNF-alpha), interleukin-6, leptin, and adiponectin were measured. In the pioglitazone group, eNOS, iNOS, and leptin were significantly lower and adiponectin was significantly higher than those in the IR group. Stepwise multiple regression analyses showed that eNOS correlated with TNF-alpha and iNOS correlated with leptin and TNF-alpha. Leptin was the strongest predictor of iNOS. Treatment with pioglitazone significantly reduced eNOS and iNOS by improving adipocytokine levels.
- Subjects :
- Male
medicine.medical_specialty
Nitric Oxide Synthase Type III
Endocrinology, Diabetes and Metabolism
Nitric Oxide Synthase Type II
Enzyme-Linked Immunosorbent Assay
Coronary Artery Disease
Type 2 diabetes
Nitric oxide
chemistry.chemical_compound
Insulin resistance
Enos
Internal medicine
Internal Medicine
medicine
Humans
Hypoglycemic Agents
Angioplasty, Balloon, Coronary
Aged
Pioglitazone
Adiponectin
biology
business.industry
Leptin
medicine.disease
biology.organism_classification
Nitric oxide synthase
Treatment Outcome
Endocrinology
Diabetes Mellitus, Type 2
chemistry
biology.protein
Thiazolidinediones
Insulin Resistance
Nitric Oxide Synthase
Cardiology and Cardiovascular Medicine
business
Follow-Up Studies
medicine.drug
Subjects
Details
- ISSN :
- 15594572 and 15594564
- Volume :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of the CardioMetabolic Syndrome
- Accession number :
- edsair.doi.dedup.....91f9f4ede63b635944369cf252fc4030