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A nationwide survey of pediatric acquired demyelinating syndromes in Japan
- Source :
- Neurology
- Publication Year :
- 2016
- Publisher :
- Lippincott Williams & Wilkins, 2016.
-
Abstract
- Objective: To investigate the clinical and epidemiologic features of pediatric acquired demyelinating syndromes (ADS) of the CNS in Japan. Methods: We conducted a nationwide survey and collected clinical data on children with ADS aged 15 years or younger, who visited hospitals between 2005 and 2007. Results: Among 977 hospitals enrolled, 723 (74.0%) responded to our inquiries and reported a total of 439 patients as follows: 244 with acute disseminated encephalomyelitis (ADEM), 117 with multiple sclerosis (MS), 14 with neuromyelitis optica (NMO), and 64 with other ADS. We collected and analyzed detailed data from 204 cases, including those with ADEM (66), MS (58), and NMO (10). We observed the following: (1) the estimated annual incidence rate of pediatric ADEM in Japan was 0.40 per 100,000 children (95% confidence interval [CI], 0.34–0.46), with the lowest prevalence in the north; (2) the estimated prevalence rate of MS was 0.69 per 100,000 children (95% CI, 0.58–0.80), with the lowest prevalence in the south; (3) NMO in Japan was rare, with an estimated prevalence of 0.06 per 100,000 children (95% CI, 0.04–0.08); and (4) the sex ratio and mean age at onset varied by ADS type, and (5) male/female ratios correlated with ages at onset in each ADS group. Conclusions: Our results clarify the characteristic clinical features of pediatric ADS in the Japanese population.
- Subjects :
- Male
Pediatrics
medicine.medical_specialty
Prevalence
Detailed data
Nationwide survey
Methylprednisolone
Article
03 medical and health sciences
0302 clinical medicine
Japan
030225 pediatrics
Surveys and Questionnaires
medicine
Humans
Child
Retrospective Studies
Neuromyelitis optica
business.industry
Multiple sclerosis
Retrospective cohort study
medicine.disease
Magnetic Resonance Imaging
Confidence interval
Child, Preschool
Acute disseminated encephalomyelitis
Female
Steroids
Neurology (clinical)
business
030217 neurology & neurosurgery
Immunosuppressive Agents
Demyelinating Diseases
Follow-Up Studies
Subjects
Details
- Language :
- English
- ISSN :
- 1526632X and 00283878
- Volume :
- 87
- Issue :
- 19
- Database :
- OpenAIRE
- Journal :
- Neurology
- Accession number :
- edsair.doi.dedup.....91eb54ecad19b21d82e6d6f5109ef91f