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Significance of systemic immune-inflammation index in the differential diagnosis of high- and low-grade gliomas
- Source :
- Clinical Neurology and Neurosurgery. 164:50-52
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Objective Circulating biomarkers have been increasingly appreciated in the grading of gliomas. This study aimed to assess the value of the systemic immune-inflammation index (SII) as a possible marker in the grading of gliomas. Materials and methods In our study, 153 patients with gliomas were included—53 patients had histologically verified low grade gliomas (LGG) and 100 patients had high grade gliomas (HGG). Preoperative complete blood count (CBC) and clinicopathological data were collected. The optimal SII cut-off value for grading of gliomas was calculated by receiver operating characteristics curve (ROC) analysis. Results Based on the ROC analysis, the most optimal cut-off value of SII to distinguish HGG and LGG was determined as 392.48 × 109/L. For this cut-off value, SII had a sensitivity of 75%, specificity of 66%, and area under the curve (AUC) of 0.773. Furthermore, we found that patients in the high-SII group had a significantly higher Ki-67 index than that in patients in the low-SII group (P = 0.002). Conclusion Our results demonstrate that SII has a moderate diagnostic accuracy for differentiating HGG from LGG. More studies are needed to confirm these results.
- Subjects :
- Adult
Male
medicine.medical_specialty
Pathology
Adolescent
Severity of Illness Index
Gastroenterology
Diagnosis, Differential
Young Adult
03 medical and health sciences
0302 clinical medicine
Glioma
Internal medicine
medicine
Humans
In patient
Grading (tumors)
Aged
Retrospective Studies
Aged, 80 and over
Inflammation
medicine.diagnostic_test
Receiver operating characteristic
Brain Neoplasms
business.industry
Area under the curve
Complete blood count
General Medicine
Middle Aged
medicine.disease
030220 oncology & carcinogenesis
Female
Surgery
Neurology (clinical)
Neoplasm Grading
Differential diagnosis
business
030217 neurology & neurosurgery
Immune inflammation
Subjects
Details
- ISSN :
- 03038467
- Volume :
- 164
- Database :
- OpenAIRE
- Journal :
- Clinical Neurology and Neurosurgery
- Accession number :
- edsair.doi.dedup.....91ea0ff909b4ab8b141bf593c3d33859