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A multicenter, randomized, and double-blind phase IV clinical trial to compare the efficacy and safety of fixed-dose combinations of amlodipine orotate/valsartan 5/160 mg versus valsartan/hydrochlorothiazide 160/12.5 mg in patients with essential hypertension uncontrolled by valsartan 160 mg monotherapy
- Source :
- Medicine
- Publication Year :
- 2018
-
Abstract
- Background: To determine whether the effectiveness and safety of fixed-dose combinations (FDCs) of amlodipine orotate/valsartan (AML/VAL) 5/160 mg are noninferior to those of valsartan/hydrochlorothiazide (VAL/HCTZ) 160/12.5 mg in hypertensive patients with inadequate response to valsartan 160 mg monotherapy. Methods: This 8-week, active-controlled, parallel-group, fixed-dose, multicenter, double-blind randomized controlled, and noninferiority trial was conducted at 17 cardiovascular centers in the Republic of Korea. Eligible patients had mean sitting diastolic blood pressure (msDBP) ≥90 mm Hg despite monotherapy with valsartan 160 mg for 4 weeks. Patients were randomly assigned to treatment with AML/VAL 5/160 mg FDC (AML/VAL) group or VAL/HCTZ 160/12.5 mg FDC (VAL/HCTZ) group once daily for 8 weeks. A total of 238 patients were enrolled (AML/VAL group, n = 121; VAL/HCTZ group, n = 117), of whom 228 completed the study. Results: At 8 weeks after randomization, msDBP was significantly decreased in both groups (−9.44 ± 0.69 mm Hg in the AML/VAL group and −7.47 ± 0.71 mm Hg in the VAL/HCTZ group, both P
- Subjects :
- Male
medicine.medical_specialty
Randomization
hypertension
Urology
Blood Pressure
030204 cardiovascular system & hematology
Essential hypertension
valsartan
law.invention
03 medical and health sciences
0302 clinical medicine
Hydrochlorothiazide
Randomized controlled trial
Double-Blind Method
law
Medicine
Humans
030212 general & internal medicine
Amlodipine
amlodipine orotate
Antihypertensive Agents
Aged
business.industry
General Medicine
Clinical Trial/Experimental Study
Middle Aged
medicine.disease
Amlodipine, Valsartan Drug Combination
Clinical trial
fixed-dose combination
Drug Combinations
Treatment Outcome
Valsartan
Valsartan/hydrochlorothiazide
Drug Therapy, Combination
Female
Essential Hypertension
business
medicine.drug
Research Article
Subjects
Details
- ISSN :
- 15365964
- Volume :
- 97
- Issue :
- 37
- Database :
- OpenAIRE
- Journal :
- Medicine
- Accession number :
- edsair.doi.dedup.....91e9f3f9bac192a144bcab04e7c598e4