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Retinoid X receptors: X-ploring their (patho)physiological functions
- Source :
- Cell Death & Differentiation. 11:S126-S143
- Publication Year :
- 2004
- Publisher :
- Springer Science and Business Media LLC, 2004.
-
Abstract
- Retinoid X receptor (RXR) belongs to a family of ligand-activated transcription factors that regulate many aspects of metazoan life. A class of nuclear receptors requires RXR as heterodimerization partner for their function. This places RXR in the crossroad of multiple distinct biological pathways. This and the fact that the debate on the endogenous ligand requirement for RXR is not yet settled make RXR still an enigmatic transcription factor. Here, we review some of the biology of RXR. We place RXR into the evolution of nuclear receptors, review structural details and ligands of the receptor. Then processes regulated by RXR are discussed focusing on the developmental roles deduced from studies on knockout animals and metabolic roles in diseases such as diabetes and atherosclerosis deduced from pharmacological studies. Finally, aspects of RXR's involvement in myeloid differentiation and apoptosis are summarized along with issues on RXR's suitability as a therapeutic target.
- Subjects :
- medicine.drug_class
Receptors, Cytoplasmic and Nuclear
Apoptosis
Biológiai tudományok
Retinoid X receptor
Biology
Ligands
environment and public health
Protein Structure, Secondary
Biological pathway
Természettudományok
Transcription (biology)
medicine
Animals
Humans
Retinoid
Receptor
Molecular Biology
Transcription factor
Phylogeny
Cell Differentiation
Cell Biology
Cell biology
body regions
Retinoid X Receptors
Nuclear receptor
Biochemistry
embryonic structures
lipids (amino acids, peptides, and proteins)
Insulin Resistance
hormones, hormone substitutes, and hormone antagonists
Subjects
Details
- ISSN :
- 14765403 and 13509047
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Cell Death & Differentiation
- Accession number :
- edsair.doi.dedup.....91e36cfe69c013a7289b537a3855611e