Coupled plasma filtration adsorption in peritonitis-induced porcine hyperdynamic septic shock

Extracorporeal blood purification techniques for the treatment of sepsis remain conceptually sound but are still an unresolved issue. Coupled plasma filtration adsorption (CPFA) enabling higher nonselective elimination of septic mediators represents a promising concept [1]. Its efficacy, however, has not been tested in a clinically relevant large animal model of septic shock. We therefore evaluated the biological effects of CPFA in a porcine long-term, hyperdynamic, peritonitis-induced septic shock model.