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Exclusive B-cell phenotype of primary prostatic lymphomas: a potential role of chronic prostatitis
- Source :
- HistopathologyReferences. 76(5)
- Publication Year :
- 2019
-
Abstract
- Aims Primary prostatic lymphomas (PPL) is exceedingly rare. The aim of this study was to investigate the largest series of PPL obtained from a nationwide expert pathologist network, and thus try to understand the pathophysiology of these tumours. Methods and results Up to 66 000 lymphoma cases have been collected and submitted for central expert review by the French Lymphopath network. We confirm the low frequency of PPL (n = 77; 0.12%), all cases being of B-cell origin. Diffuse large B-cell lymphoma and small lymphocytic lymphoma were the most frequent subtypes, comprising 31% and 26% of cases respectively, followed by mucosa-associated lymphoid tissue (MALT)/lymphoplasmacytic lymphoma (19%), follicular lymphoma (12%), mantle cell lymphoma (6%), Burkitt lymphoma (4%), and unclassified lymphoma (1%). Clinical data obtained in 25 cases suggests that PPLs are rather indolent tumours. Our hypothesis for B-cell recruitment in the prostatic tissue was derived from the observation in chronic inflammation (prostatitis) of frequent heterotopic proliferation of high endothelial venules (HEVs). The latter are dedicated to lymphocyte entry into secondary lymphoid organs, here putatively driving circulating clonal B-lymphocytes from the blood into the inflamed prostate. This may account for the relatively high incidence of small lymphocytic lymphoma consistently reported in series of primary or secondary prostatic lymphoma. As in other organs or glands, chronic inflammation may promote antigen-dependent intraprostatic MALT lymphoma and diffuse large B-cell lymphoma development. Conclusions PPLs are exclusively of B-cell origin, and chronic inflammation resulting from the proliferation of high endothelial venules could play some role in their development.
- Subjects :
- 0301 basic medicine
Adult
Male
Pathology
medicine.medical_specialty
Histology
Lymphoma, B-Cell
High endothelial venules
Follicular lymphoma
Prostatitis
Pathology and Forensic Medicine
Lymphoplasmacytic Lymphoma
03 medical and health sciences
0302 clinical medicine
immune system diseases
hemic and lymphatic diseases
medicine
Humans
B cell
Aged
Aged, 80 and over
B-Lymphocytes
business.industry
Prostatic Neoplasms
MALT lymphoma
General Medicine
Middle Aged
medicine.disease
Lymphoma
030104 developmental biology
medicine.anatomical_structure
Phenotype
030220 oncology & carcinogenesis
Mantle cell lymphoma
business
Subjects
Details
- ISSN :
- 13652559
- Volume :
- 76
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- HistopathologyReferences
- Accession number :
- edsair.doi.dedup.....91a7a123f3db57f070fd0f279f28793d