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Soluble Polymer-Supported Synthesis of 5-Arylidene Thiazolidinones and Pyrimidinones Using a Novel Traceless Linker Strategy
- Source :
- Journal of Combinatorial Chemistry. 10:632-636
- Publication Year :
- 2008
- Publisher :
- American Chemical Society (ACS), 2008.
-
Abstract
- An efficient method for the soluble polymer-supported synthesis of 5-arylidene thiazolidinones and pyrimidinones using aniline as a traceless linker was described. Aldehyde substrates were attached to the polyethylene glycol (PEG)-bound aniline via an imine linkage, and after the subsequent PEG-promoted Suzuki coupling reaction for the diversification, Knoevenagel condensation was readily employed as the cleavage strategy.
- Subjects :
- Magnetic Resonance Spectroscopy
Imine
Hydrocarbons, Cyclic
Pyrimidinones
Polyethylene glycol
Aldehyde
Polyethylene Glycols
chemistry.chemical_compound
Aniline
Suzuki reaction
Combinatorial Chemistry Techniques
Protein Tyrosine Phosphatase, Non-Receptor Type 1
chemistry.chemical_classification
Aniline Compounds
technology, industry, and agriculture
General Chemistry
Combinatorial chemistry
Models, Chemical
Solubility
chemistry
Colorimetry
Thiazolidinediones
Knoevenagel condensation
Imines
Linker
Subjects
Details
- ISSN :
- 15204774 and 15204766
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Journal of Combinatorial Chemistry
- Accession number :
- edsair.doi.dedup.....91a5e376771d1767bc15c71ae352e5b3