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MRI Monitoring of the Mixed State of Admixtures Consisting of Moisturizing Cream and Steroid Ointment during the Mixing Process by a Revolution/Rotation-Type Hybrid Mixer

Authors :
Haruna Setoyama
Yasuko Obata
Yoshiaki Machida
Masamitsu Yokokawa
Yoshinori Onuki
Yoshihiro Hayashi
Kotaro Okada
Source :
Chemical and Pharmaceutical Bulletin. 66:1078-1082
Publication Year :
2018
Publisher :
Pharmaceutical Society of Japan, 2018.

Abstract

The admixture of a steroid ointment and a moisturizing cream is frequently prescribed to patients suffering from atopic dermatitis. For the mixing operation, a revolution/rotation-type hybrid mixer is widely used in pharmacy. The purpose of this study was to monitor the mixed state of the admixtures during the mixing process of the hybrid mixer. The key technology used in this study was magnetic resonance imaging (MRI). Two different commercial mometasone furoate-containing ointments were used as a test steroid ointment. After layering the moisturizing cream and the steroid ointment in an ointment bottle, the sample was mixed for a predetermined period using the hybrid mixer. According to MRI transverse relaxation time (T2) mapping for nondestructive monitoring, it was confirmed that the Flumeta® ointment-containing admixture became homogeneous by mixing for 60 s or more. As for the mometasone furoate ointment 0.1%-containing admixture, the mixed state, after becoming homogeneous, was separated into two layers again by the prolonged mixing process. From the 1H-NMR spectra of the phase-separated layers, re-separation was caused by removing aqueous components from the bottom of the samples. MRI is a powerful tool for monitoring the mixed state of the admixture during the mixing process. We believe that our findings offer profound insights into the clinical practice of the mixing operation using a hybrid mixer.

Details

ISSN :
13475223 and 00092363
Volume :
66
Database :
OpenAIRE
Journal :
Chemical and Pharmaceutical Bulletin
Accession number :
edsair.doi.dedup.....918b68638e4bb45dac16352460d1cd75
Full Text :
https://doi.org/10.1248/cpb.c18-00490