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How to show that unicorn milk is a chronobiotic: the regression-to-the-mean statistical artifact

How to show that unicorn milk is a chronobiotic: the regression-to-the-mean statistical artifact

Authors :
Jim Waterhouse
Greg Atkinson
Ben Edwards
Thomas Reilly
Source :
Chronobiology international. 18(6)
Publication Year :
2002

Abstract

Few chronobiologists may be aware of the regression-to-the-mean (RTM) statistical artifact, even though it may have far-reaching influences on chronobiological data. With the aid of simulated measurements of the circadian rhythm phase of body temperature and a completely bogus stimulus (unicorn milk), we explain what RTM is and provide examples relevant to chronobiology. We show how RTM may lead to erroneous conclusions regarding individual differences in phase responses to rhythm disturbances and how it may appear as though unicorn milk has phase-shifting effects and can successfully treat some circadian rhythm disorders. Guidelines are provided to ensure RTM effects are minimized in chronobiological investigations.

Details

ISSN :
07420528
Volume :
18
Issue :
6
Database :
OpenAIRE
Journal :
Chronobiology international
Accession number :
edsair.doi.dedup.....91883644af1b11979026423568172ff3