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Association of Mps one binder kinase activator 1 (MOB1) expression with poor disease‐free survival in individuals with non‐small cell lung cancer
- Source :
- Thoracic Cancer, Vol 11, Iss 10, Pp 2830-2839 (2020), Thoracic Cancer
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- Background Mps one binder kinase activator 1 (MOB1) is a core component of the Hippo signaling pathway and has been implicated as a tumor suppressor. Here, we evaluated the possible relationship of MOB1 expression in non‐small cell lung cancer (NSCLC) to prognosis. Methods We retrospectively analyzed 205 lung adenocarcinoma patients treated at Kyushu University Hospital between November 2007 and October 2012. MOB1 expression in tumor cells of surgical specimens was evaluated by immunohistochemistry. Invasive activity of NSCLC cell lines in vitro was measured with a transwell assay. Results Expression of MOB1 was classified as high in 105 of the 205 (51.2%) tumor specimens, and such high expression was significantly associated with poor disease‐free survival (P = 0.0161). Among the various clinicopathologic parameters examined, high MOB1 expression was significantly associated only with intratumoral vascular invasion (P = 0.0005). Multivariate analysis also identified high MOB1 expression as a significant independent risk factor for disease‐free survival (P = 0.0319). The invasiveness of H1299 cells in vitro was increased or attenuated by overexpression or knockdown of MOB1, respectively. Conclusions Our results suggest that MOB1 might promote early recurrence of NSCLC by increasing vascular invasion by tumor cells. Key points Significant findings of the study We found that high MOB1 expression in surgical specimens of lung adenocarcinoma was associated with poor disease‐free survival and with intratumoral vascular invasion. MOB1 expression also promoted the invasiveness of NSCLC cells in vitro. What this study adds Our results thus suggest that high MOB1 expression is a risk factor for early postoperative recurrence in lung adenocarcinoma.<br />We found that high MOB1 expression in surgical specimens of lung adenocarcinoma was associated with poor disease‐free survival and with intratumoral vascular invasion. MOB1 expression also promoted the invasiveness of NSCLC cells in vitro. Our results suggest that MOB1 might contribute to early recurrence in NSCLC.
- Subjects :
- 0301 basic medicine
Pulmonary and Respiratory Medicine
Male
Lung Neoplasms
Hippo pathway
lcsh:RC254-282
Disease-Free Survival
03 medical and health sciences
0302 clinical medicine
Carcinoma, Non-Small-Cell Lung
medicine
Humans
Risk factor
Lung cancer
vascular invasion
Aged
Retrospective Studies
Hippo signaling pathway
Gene knockdown
Lung
business.industry
General Medicine
Original Articles
medicine.disease
lung adenocarcinoma
MOB1
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
In vitro
Chemokine CXCL10
030104 developmental biology
medicine.anatomical_structure
Oncology
030220 oncology & carcinogenesis
immunohistochemistry
Cancer research
Immunohistochemistry
Adenocarcinoma
Original Article
Female
business
Subjects
Details
- Language :
- English
- ISSN :
- 17597706 and 17597714
- Volume :
- 11
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Thoracic Cancer
- Accession number :
- edsair.doi.dedup.....917db0abba176ccd139d46a4c6d18092