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Selective effect of cell membrane on synaptic neurotransmission
- Source :
- Scientific Reports, Postila, P A, Vattulainen, I & Róg, T 2016, ' Selective effect of cell membrane on synaptic neurotransmission ', Scientific Reports, vol. 6, 19345 . https://doi.org/10.1038/srep19345
- Publication Year :
- 2016
- Publisher :
- Springer Science and Business Media LLC, 2016.
-
Abstract
- Atomistic molecular dynamics simulations were performed with 13 non-peptidic neurotransmitters (NTs) in three different membrane environments. The results provide compelling evidence that NTs are divided into membrane-binding and membrane-nonbinding molecules. NTs adhere to the postsynaptic membrane surface whenever the ligand-binding sites of their synaptic receptors are buried in the lipid bilayer. In contrast, NTs that have extracellular ligand-binding sites do not have a similar tendency to adhere to the membrane surface. This finding is a seemingly simple yet important addition to the paradigm of neurotransmission, essentially dividing it into membrane-independent and membrane-dependent mechanisms. Moreover, the simulations also indicate that the lipid composition especially in terms of charged lipids can affect the membrane partitioning of NTs. The revised paradigm, highlighting the importance of cell membrane and specific lipids for neurotransmission, should to be of interest to neuroscientists, drug industry and the general public alike.
- Subjects :
- Models, Molecular
0301 basic medicine
Molecular Conformation
Synaptic Membranes
AGONIST DYSIHERBAINE
Neurotransmission
Biology
114 Physical sciences
Models, Biological
Synaptic Transmission
Article
Cell membrane
03 medical and health sciences
PLASMA-MEMBRANES
Extracellular
medicine
PERMEABILITY
Lipid bilayer
Receptor
AFFINITY
Neurotransmitter Agents
Binding Sites
Multidisciplinary
RECEPTOR
CHOLESTEROL
Cell Membrane
Transporter
respiratory system
TRANSPORTERS
Cell biology
030104 developmental biology
Membrane
medicine.anatomical_structure
nervous system
MOLECULAR-DYNAMICS
Synapses
FORCE-FIELD
1182 Biochemistry, cell and molecular biology
LIPID-BILAYER MEMBRANES
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....916dead52ed98478514f4908d5389a28