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Epidemiological profile of multidrug-resistant and extensively drug-resistant Mycobacterium Tubrculosis among Congolese patients
- Source :
- Annals of clinical microbiology and antimicrobials, 20(1):84. BioMed Central, Annals of Clinical Microbiology and Antimicrobials, Annals of Clinical Microbiology and Antimicrobials, Vol 20, Iss 1, Pp 1-8 (2021)
- Publication Year :
- 2021
-
Abstract
- Background There is paucity of data on the prevalence and distribution of multidrug- Resistant-Tuberculosis (MDR-TB) in the Republic of Congo. Among the challenges resides the implementation of a robust TB resistance diagnostic program using molecular tools. In resource limited settings there is a need to gather data to enable prioritization of actions. The objective of this study was is to implement molecular tools as a best of diagnosing MDR and XDR-TB among presumptive tuberculosis patients referred to reference hospital of Makelekele in Brazzaville, Republic of the Congo. Methods We have conducted a cross-sectional study, including a total of 92 presumptive pulmonary tuberculosis patients and who had never received treatment recruited at the reference hospital of Makelekele from October 2018 to October 2019. The socio-demographic and clinical data were collected as well as sputum samples. Rifampicin resistance was investigated using Xpert (Cepheid) and second-line TB drugs Susceptibility testing were performed by the Brucker HAIN Line Probe Assay (GenoType MTBDRsl VER 2.0 assay) method. Results From the 92 recruited patients, 57 (62%) were found positive for the Mycobacterium tuberculosis complex. The prevalence of rifampicin-resistant tuberculosis (RR-TB) was 9.8% (9/92) and importantly 2.2% were pre-XDR/XDR. Conclusion This study showed a high rate of rifampicin resistance and the presence of extensively drug-resistant tuberculosis in the study area in new patients. This study highlights the need for further studies of TB drug resistance in the country.
- Subjects :
- Microbiology (medical)
Adult
Male
Adolescent
Extensively Drug-Resistant Tuberculosis
Multidrug-resistant TB
Republic of Congo
Antitubercular Agents
Extensively drug-resistant TB
RM1-950
Infectious and parasitic diseases
RC109-216
Microbial Sensitivity Tests
Xpert MTB / RIF
Microbiology
Young Adult
Tuberculosis, Multidrug-Resistant
Epidemiological profile
Humans
Line Probe Assay SL
Research
Sputum
General Medicine
Mycobacterium tuberculosis
QR1-502
Infectious Diseases
Cross-Sectional Studies
Congo
Female
Therapeutics. Pharmacology
Rifampin
Subjects
Details
- Language :
- English
- ISSN :
- 14760711
- Volume :
- 20
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Annals of clinical microbiology and antimicrobials
- Accession number :
- edsair.doi.dedup.....916b4abf4c33299a535fa201ea3f3481