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In-beam quality assurance using induced β(+) activity in hadrontherapy: a preliminary physical requirements study using Geant4
- Source :
- Physics in Medicine and Biology, Physics in Medicine and Biology, IOP Publishing, 2012, 57, pp.6497. ⟨10.1088/0031-9155/57/20/6497⟩, Physics in Medicine and Biology, 2012, 57, pp.6497. ⟨10.1088/0031-9155/57/20/6497⟩
- Publication Year :
- 2012
-
Abstract
- Light and heavy ions particle therapy, mainly by means of protons and carbon ions, represents an advantageous treatment modality for deep-seated and/or radioresistant tumours. An in-beam quality assurance principle is based on the detection of secondary particles induced by nuclear fragmentations between projectile and target nuclei. Three different strategies are currently under investigation: prompt γ rays imaging, proton interaction vertex imaging and in-beam positron emission tomography. Geant4 simulations have been performed first in order to assess the accuracy of some hadronic models to reproduce experimental data. Two different kinds of data have been considered: β(+)-emitting isotopes and prompt γ-ray production rates. On the one hand simulations reproduce experimental β(+) emitting isotopes production rates to an accuracy of 24%. Moreover simulated β(+) emitting nuclei production rate as a function of depth reproduce well the peak-to-plateau ratio of experimental data. On the other hand by tuning the tolerance factor of the photon evaporation model available in Geant4, we reduce significantly prompt γ-ray production rates until a very good agreement is reached with experimental data. Then we have estimated the total amount of induced annihilation photons and prompt γ rays for a simple treatment plan of ∼1 physical Gy in a homogenous equivalent soft tissue tumour (6 cm depth, 4 cm radius and 2 cm wide). The average annihilation photons emitted during a 45 s irradiation in a 4 π solid angle are ∼2 × 10(6) annihilation photon pairs and 10(8) single prompt γ whose energy ranges from a few keV to 10 MeV.
- Subjects :
- Quality Control
Photon
Proton
medicine.medical_treatment
Astrophysics::High Energy Astrophysical Phenomena
Hadron
Geant4
Heavy Ion Radiotherapy
01 natural sciences
030218 nuclear medicine & medical imaging
Ion
Nuclear physics
Physical Phenomena
03 medical and health sciences
0302 clinical medicine
hadrontherapy
0103 physical sciences
medicine
Radiology, Nuclear Medicine and imaging
Irradiation
Physics
Annihilation
Particle therapy
Radiological and Ultrasound Technology
Isotope
010308 nuclear & particles physics
Radiotherapy Planning, Computer-Assisted
Beta Particles
[PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph]
Atomic physics
Monte Carlo Method
Subjects
Details
- ISSN :
- 13616560 and 00319155
- Volume :
- 57
- Issue :
- 20
- Database :
- OpenAIRE
- Journal :
- Physics in medicine and biology
- Accession number :
- edsair.doi.dedup.....91687b94a440b3d32a0d917e305d8b83