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Zika Virus Meningoencephalitis in an Immunocompromised Patient
- Source :
- Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual), Universidade de São Paulo (USP), instacron:USP
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- The World Health Organization considers the Zika virus (ZIKV) outbreak in the Americas a global public health emergency. The neurologic complications due to ZIKV infection comprise microcephaly, meningoencephalitis, and Guillain-Barre syndrome. We describe a fatal case of an adult patient receiving an immunosuppressive regimen following heart transplant. The patient was admitted with acute neurologic impairment and experienced progressive hemodynamic instability and mental deterioration that finally culminated in death. At autopsy, a pseudotumoral form of ZIKV meningoencephalitis was confirmed. Zika virus infection was documented by reverse trancriptase-polymerase chain reaction, immunohistochemistry, and immunofluorescence and electron microscopy of the brain parenchyma and cerebral spinal fluid. The sequencing of the viral genome in this patient confirmed a Brazilian ZIKV strain. In this case, central nervous system involvement and ZIKV propagation to other organs in a disseminated pattern is quite similar to that observed in other fatal Flaviviridae viral infections.
- Subjects :
- Heart transplantation
Microcephaly
biology
business.industry
medicine.medical_treatment
Outbreak
Meningoencephalitis
Autopsy
General Medicine
medicine.disease
biology.organism_classification
Virology
Zika virus
03 medical and health sciences
Flaviviridae
FÁRMACOS IMUNOSSUPRESSORES
0302 clinical medicine
Cerebrospinal fluid
Medicine
030212 general & internal medicine
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 00256196
- Volume :
- 92
- Database :
- OpenAIRE
- Journal :
- Mayo Clinic Proceedings
- Accession number :
- edsair.doi.dedup.....9157ce42855b54beb5713a1e4c9160de