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BCL2DB: database of BCL-2 family members and BH3-only proteins
- Source :
- Database: The Journal of Biological Databases and Curation
- Publication Year :
- 2014
-
Abstract
- BCL2DB (http://bcl2db.ibcp.fr) is a database designed to integrate data on BCL-2 family members and BH3-only proteins. These proteins control the mitochondrial apoptotic pathway and probably many other cellular processes as well. This large protein group is formed by a family of pro-apoptotic and anti-apoptotic homologs that have phylogenetic relationships with BCL-2, and by a collection of evolutionarily and structurally unrelated proteins characterized by the presence of a region of local sequence similarity with BCL-2, termed the BH3 motif. BCL2DB is monthly built, thanks to an automated procedure relying on a set of homemade profile HMMs computed from seed reference sequences representative of the various BCL-2 homologs and BH3-only proteins. The BCL2DB entries integrate data from the Ensembl, Ensembl Genomes, European Nucleotide Archive and Protein Data Bank databases and are enriched with specific information like protein classification into orthology groups and distribution of BH motifs along the sequences. The Web interface allows for easy browsing of the site and fast access to data, as well as sequence analysis with generic and specific tools. BCL2DB provides a helpful and powerful tool to both 'BCL-2-ologists' and researchers working in the various fields of physiopathology. Database URL: http://bcl2db.ibcp.fr.
- Subjects :
- Protein structure database
European Nucleotide Archive
Protein family
Sequence analysis
Molecular Sequence Data
Biology
computer.software_genre
General Biochemistry, Genetics and Molecular Biology
User-Computer Interface
Ensembl Genomes
Ensembl
Animals
Humans
Amino Acid Sequence
Databases, Protein
Internet
Database
Molecular Sequence Annotation
computer.file_format
Structural Classification of Proteins database
Protein Data Bank
Database Tool
Proto-Oncogene Proteins c-bcl-2
Multigene Family
General Agricultural and Biological Sciences
computer
Information Systems
Subjects
Details
- ISSN :
- 17580463
- Volume :
- 2014
- Database :
- OpenAIRE
- Journal :
- Database : the journal of biological databases and curation
- Accession number :
- edsair.doi.dedup.....9142a47fdd8758452b1048e61571637b