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Alumina Ceramic Exacerbates the Inflammatory Disease by Activation of Macrophages and T Cells
- Source :
- International Journal of Molecular Sciences, Volume 21, Issue 19, International Journal of Molecular Sciences, Vol 21, Iss 7114, p 7114 (2020)
- Publication Year :
- 2020
-
Abstract
- (1) Background: Aluminum oxide (Al2O3) ceramic is one of the materials used for artificial joints, and it has been known that their fine particles (FPs) are provided by the wear of the ceramic. Al2O3 FPs have been shown to induce macrophage activation in vitro<br />however, the inflammatory effect in vivo has not been studied. (2) Methods: We examined the in vivo effect of Al2O3 FPs on the innate and adaptive immune cells in the mice. (3) Results: Al2O3 FPs promoted the activation of spleen macrophages<br />however, conventional dendritic cells (cDCs), plasmacytoid DCs (pDCs), and natural killer (NK) cells were not activated. In addition, increases in the CD4 and CD8 T cells was induced in the spleens of the mice treated with Al2O3 FPs, which differentiated into interferon-gamma (IFN-&gamma<br />)-producing helper T1 (Th1) and cytotoxic T1 (Tc1) cells. Finally, the injection of Al2O3 FPs exacerbated dextran sulfate sodium (DSS)-induced inflammation in the colon, mediated by activated and increased number of CD4 and CD8 T cells. (4) Conclusions: These data demonstrate that FPs of Al2O3 ceramic may contribute to the exacerbation of inflammatory diseases in the patients.
- Subjects :
- Ceramics
animal structures
health care facilities, manpower, and services
T-Lymphocytes
education
Inflammation
Spleen
Biocompatible Materials
Al2O3 FP
macrophage
Lymphocyte Activation
Catalysis
Article
Inorganic Chemistry
lcsh:Chemistry
Mice
Immune system
In vivo
medicine
Aluminum Oxide
Cytotoxic T cell
Macrophage
Animals
Physical and Theoretical Chemistry
Particle Size
Molecular Biology
lcsh:QH301-705.5
Spectroscopy
health care economics and organizations
Chemistry
Macrophages
Organic Chemistry
General Medicine
CD4 T cell
Macrophage Activation
In vitro
Computer Science Applications
Mice, Inbred C57BL
medicine.anatomical_structure
lcsh:Biology (General)
lcsh:QD1-999
CD8 T cell
Alumina ceramic
embryonic structures
Cancer research
medicine.symptom
Subjects
Details
- ISSN :
- 14220067
- Volume :
- 21
- Issue :
- 19
- Database :
- OpenAIRE
- Journal :
- International journal of molecular sciences
- Accession number :
- edsair.doi.dedup.....91283fd74855a9e0287f34268a3eb222