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Overexpression of VEGF-C correlates with a poor prognosis in esophageal cancer patients
- Source :
- Cancer Biomarkers. 17:165-170
- Publication Year :
- 2016
- Publisher :
- IOS Press, 2016.
-
Abstract
- The prognostic value of vascular endothelial growth factor C (VEGF-C) in patients with esophageal cancer (EC) remains controversial. The aim of this meta-analysis was to clarify the association of VEGF-C with survival in EC patients.We performed a meta-analysis that included eligible studies to expound the effect of VEGF-C in EC survival. Eligible studies published until November 2015 was identified using available databases. STATA 12.0 was performed in this meta-analysis.We identified 13 studies, including 1203 patients, in this meta-analysis. The combined hazard ratio of 1.70 (95% CI, 1.43-2.03, P0.001) shows that VEGF-C overexpression was significantly correlated with poor overall survival in EC patients. Furthermore, the results suggested a significant relationship between VEGF-C expression and overall survival was also showed in studies with patient source, patient number ≥ 70, methods detecting VEGF-C by reverse transcription PCR (RT-PCR) or ELISA and histology type. Moreover, combined odds ratio of VEGF-C displayed that VEGF-C overexpression was significantly association with stage, depth of tumor invasion, lymph node status and metastasis of EC (P0.05). However, it has no correlation with differentiation degree of EC (P0.05).VEGF-C overexpression shows an unfavorable prognosis for EC patients.
- Subjects :
- 0301 basic medicine
Oncology
Cancer Research
medicine.medical_specialty
Pathology
Poor prognosis
Esophageal Neoplasms
VEGF receptors
Vascular Endothelial Growth Factor C
Gene Expression
03 medical and health sciences
0302 clinical medicine
Internal medicine
Biomarkers, Tumor
Odds Ratio
Genetics
medicine
Humans
In patient
Neoplasm Staging
biology
business.industry
Hazard ratio
General Medicine
Esophageal cancer
Prognosis
medicine.disease
030104 developmental biology
Vascular endothelial growth factor C
030220 oncology & carcinogenesis
Meta-analysis
biology.protein
Neoplasm Grading
business
Publication Bias
Subjects
Details
- ISSN :
- 18758592 and 15740153
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Cancer Biomarkers
- Accession number :
- edsair.doi.dedup.....91255cbcf0afef256f2dd60cbbdf7fbb