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Klebsiella oxytoca expands in cancer cachexia and acts as a gut pathobiont contributing to intestinal dysfunction
- Source :
- Scientific Reports, Scientific Reports, Vol. 8, no.1, p. 12321 [1-12] (2018), Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018), DIAL
- Publication Year :
- 2018
-
Abstract
- Cancer cachexia is a complex multi-organ syndrome characterized by body weight loss, weakness, muscle atrophy and fat depletion. With a prevalence of 1 million people in Europe and only limited therapeutic options, there is a high medical need for new approaches to treat cachexia. Our latest results highlighted microbial dysbiosis, characterized by a bloom in Enterobacteriaceae and altered gut barrier function in preclinical models of cancer cachexia. They also demonstrated the potential of targeting the gut microbial dysbiosis in this pathology. However, the exact mechanisms underlying the gut microbiota-host crosstalk in cancer cachexia remain elusive. In this set of studies, we identified Klebsiella oxytoca as one of the main Enterobacteriaceae species increased in cancer cachexia and we demonstrated that this bacteria acts as a gut pathobiont by altering gut barrier function in cachectic mice. Moreover, we propose a conceptual framework for the lower colonization resistance to K. oxytoca in cancer cachexia that involves altered host gut epithelial metabolism and host-derived nitrate boosting the growth of the gut pathobiont. This set of studies constitutes a strong progression in the field of gut microbiota in cancer cachexia, by dissecting the mechanism of emergence of one bacterium, K. oxytoca, and establishing its role as a gut pathobiont in this severe disease.
- Subjects :
- 0301 basic medicine
Male
Cachexia
lcsh:Medicine
Colonisation resistance
Gut flora
Microbial dysbiosis
digestive system
Article
03 medical and health sciences
Mice
Cell Line, Tumor
Neoplasms
medicine
Animals
lcsh:Science
Multidisciplinary
biology
business.industry
lcsh:R
digestive, oral, and skin physiology
Klebsiella oxytoca
Cancer cachexia
medicine.disease
biology.organism_classification
Enterobacteriaceae
Muscle atrophy
3. Good health
Gastrointestinal Microbiome
Gastrointestinal Tract
Intestinal Diseases
030104 developmental biology
Immunology
lcsh:Q
medicine.symptom
business
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 8
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific reports
- Accession number :
- edsair.doi.dedup.....9112f62c36171fb2e46759ab5cb6288b