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Enchancement of Toremifene Anti-Tumor Action by Metformin and Unusual Side Effect of Toremifene in Male Transgenic Mice with HER2-Positive Breast Tumor
- Source :
- Drug research. 69(12)
- Publication Year :
- 2019
-
Abstract
- HER2-positive breast tumors are found in 25–30% of patients with breast cancer and are characterized by aggressive course and reduced sensitivity to both chemotherapy and hormone therapy. The aim of the work was to study the possibilities of enhancing the therapeutic effect of anti-estrogen drug toremifene by combining it with biguanide, metformin, on the HER2-positive breast cancer model in FVB/N HER-2/neu transgenic mouse. Male FBV/N mice with intramuscularly transplanted HER2-positive mammary gland tumor from a female mouse of the same strain have been given toremifene (30 mg/kg, orally daily) or metformin (100 mg/kg, orally daily) that had a moderate antitumor effect (decrease the area under the kinetic curve of tumor growth by 1.6 and 1.5 times, respectively, when compared with intact control). Co-administration of these drugs in the same doses had a more pronounced effect (the area under the kinetic curve of tumor growth decreased by 3.1 times compared to intact control; p
- Subjects :
- Male
Side effect
medicine.drug_class
Receptor, ErbB-2
medicine.medical_treatment
Mammary gland
Antineoplastic Agents
Breast Neoplasms
Mice, Transgenic
Pharmacology
01 natural sciences
Breast Neoplasms, Male
03 medical and health sciences
Mice
0302 clinical medicine
Breast cancer
Drug Discovery
medicine
Animals
Toremifene
Chemotherapy
010405 organic chemistry
business.industry
Biguanide
Therapeutic effect
General Medicine
medicine.disease
Metformin
0104 chemical sciences
Disease Models, Animal
medicine.anatomical_structure
030220 oncology & carcinogenesis
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 21949387
- Volume :
- 69
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Drug research
- Accession number :
- edsair.doi.dedup.....90ff1577fa3647135a15b44cda5d39f3