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4-Thio-5-bromo-2′-deoxyuridine: Chemical Synthesis and Therapeutic Potential of UVA-Induced DNA Damage
- Source :
- ChemInform. 35
- Publication Year :
- 2004
- Publisher :
- Wiley, 2004.
-
Abstract
- 4-Thio-5-bromo-2'-deoxyuridine (3a) is prepared from 5-bromo-2'-deoxyuridine (BrdU) and its key properties are explored. The thionucleoside (3a) can react readily with monobromobimane and produces high fluorescence. 3a has UV maximum absorption at 340 nm and can be incorporated into cellular DNA. The cells containing 3a become sensitive to UVA light, offering therapeutic potential for UVA-induced cell killing.
- Subjects :
- Radiation-Sensitizing Agents
DNA Repair
Cell Survival
Ultraviolet Rays
DNA damage
Thiouridine
Clinical Biochemistry
Pharmaceutical Science
Antineoplastic Agents
Absorption (skin)
Radiation Tolerance
Biochemistry
Chemical synthesis
chemistry.chemical_compound
Cell Line, Tumor
Drug Discovery
Humans
Photosensitizer
Molecular Biology
Molecular Structure
Chemistry
Organic Chemistry
DNA
General Medicine
Fluorescence
Deoxyuridine
Deoxyribonucleoside
Cell killing
Biophysics
Nucleic acid
Molecular Medicine
4-thio-5-bromo-2'-deoxyuridine
Drug Screening Assays, Antitumor
Phototoxicity
DNA Damage
Subjects
Details
- ISSN :
- 15222667 and 09317597
- Volume :
- 35
- Database :
- OpenAIRE
- Journal :
- ChemInform
- Accession number :
- edsair.doi.dedup.....90f99c5b14cd157f9fb0d21944f0c3f3