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Potential Roles of Amiloride-Sensitive Sodium Channels in Cancer Development
- Source :
- BioMed Research International, BioMed Research International, Vol 2016 (2016)
- Publication Year :
- 2016
- Publisher :
- Hindawi Limited, 2016.
-
Abstract
- The ENaC/degenerin ion channel superfamily includes the amiloride-sensitive epithelial sodium channel (ENaC) and acid sensitive ionic channel (ASIC). ENaC is a multimeric ion channel formed by heteromultimeric membrane glycoproteins, which participate in a multitude of biological processes by mediating the transport of sodium (Na+) across epithelial tissues such as the kidney, lungs, bladder, and gut. Aberrant ENaC functions contribute to several human disease states including pseudohypoaldosteronism, Liddle syndrome, cystic fibrosis, and salt-sensitive hypertension. Increasing evidence suggests that ion channels not only regulate ion homeostasis and electric signaling in excitable cells but also play important roles in cancer cell behaviors such as proliferation, apoptosis, invasion, and migration. Indeed, ENaCs/ASICs had been reported to be associated with cancer characteristics. Given their cell surface localization and pharmacology, pharmacological strategies to target ENaC/ASIC family members may be promising cancer therapeutics.
- Subjects :
- 0301 basic medicine
Epithelial sodium channel
lcsh:Medicine
Apoptosis
Review Article
Bioinformatics
General Biochemistry, Genetics and Molecular Biology
Amiloride
03 medical and health sciences
Cell Movement
Neoplasms
medicine
Animals
Humans
Neoplasm Invasiveness
Epithelial Sodium Channels
Acid-sensing ion channel
Ion channel
Cell Proliferation
General Immunology and Microbiology
urogenital system
Chemistry
Sodium channel
lcsh:R
Sodium
General Medicine
respiratory system
Cell biology
Liddle Syndrome
Acid Sensing Ion Channels
030104 developmental biology
Ion homeostasis
Signal transduction
hormones, hormone substitutes, and hormone antagonists
Signal Transduction
medicine.drug
Subjects
Details
- ISSN :
- 23146141 and 23146133
- Volume :
- 2016
- Database :
- OpenAIRE
- Journal :
- BioMed Research International
- Accession number :
- edsair.doi.dedup.....90f6d398457e04558786edbf49b9c6d2