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Preparation of 188Re-labeled paper for treating skin cancer
- Source :
- Applied Radiation and Isotopes. 58:551-555
- Publication Year :
- 2003
- Publisher :
- Elsevier BV, 2003.
-
Abstract
- For homogeneous delivery of beta radiation to skin cancer, we developed a simple method for preparing (188) Re-labeled nitrocellulose paper. The homogeneity and stability of the labeled paper were investigated. Absorbed dose estimates were calculated using the Monte-Carlo method. A 74-MBq (188) Re-labeled paper with 1-cm diameter delivered 147.2 Gy up to 1-mm depth after 2-h irradiation. Animal experiments on tumor-bearing mice showed that 50 Gy is an adequate dose for treating skin cancer. Tumors disappeared 7 days after irradiation in all the groups irradiated by 50 or 100 Gy. The (188) Re-labeled paper provided a convenient, economical, effective, and non-invasive method of treating skin cancer.
- Subjects :
- Paper
Radioisotopes
Mice, Inbred BALB C
Skin Neoplasms
Radiation
business.industry
Chemistry
Collodion
Radiation Dosage
medicine.disease
Mice
Rhenium
Homogeneous
Isotope Labeling
Absorbed dose
Tumor Cells, Cultured
medicine
Animals
Irradiation
Skin cancer
Sarcoma 180
Nuclear medicine
business
Monte Carlo Method
β radiation
Subjects
Details
- ISSN :
- 09698043
- Volume :
- 58
- Database :
- OpenAIRE
- Journal :
- Applied Radiation and Isotopes
- Accession number :
- edsair.doi.dedup.....90da0817669e6adb4a1946191e2ab157