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Hypergravity enhances the therapeutic effect of dexamethasone in allergic asthma and rhinitis animal model
- Source :
- PLoS ONE, Vol 13, Iss 5, p e0197594 (2018), PLoS ONE
- Publication Year :
- 2018
- Publisher :
- Public Library of Science (PLoS), 2018.
-
Abstract
- We investigated whether the therapeutic effects of dexamethasone for allergic asthma and rhinitis were enhanced in mice when exposed to hypergravity. Forty mice were divided into 5 groups (n = 8/group): Control group received saline intraperitoneally (i.p.) and intranasally (i.n.); Asthma group received i.p./i.n. ovalbumin (OVA) for inducing allergic asthma/rhinitis; Dexa group received i.n. dexamethasone (0.75 mg/kg) 30 minutes before each OVA challenge; Hypergravity group was subjected to allergic asthma/rhinitis as well as exposed to 5 G hypergravity for 30 days; Finally in Dexa/Hypergravity group, hypergravity and dexamethasone were used simultaneously during induction of allergic asthma/rhinitis. Dexa group and Hypergravity group showed a significant decrease in serum total IgE levels compared to the Asthma group (p
- Subjects :
- 0301 basic medicine
Pulmonology
Neutrophils
Physiology
medicine.medical_treatment
Respiratory System
Drug Evaluation, Preclinical
Gene Expression
lcsh:Medicine
Pathology and Laboratory Medicine
Immunoglobulin E
Dexamethasone
Mice
White Blood Cells
0302 clinical medicine
Animal Cells
Immune Physiology
Anti-Allergic Agents
Medicine and Health Sciences
Lymphocytes
lcsh:Science
Lung
Immune Response
Saline
Mice, Inbred BALB C
Innate Immune System
Multidisciplinary
biology
Physics
musculoskeletal system
Specific Pathogen-Free Organisms
Up-Regulation
Enzyme Induction
030220 oncology & carcinogenesis
Physical Sciences
Cytokines
Female
Nasal Cavity
Cellular Types
Anatomy
Bronchoalveolar Lavage Fluid
Research Article
Gravitation
medicine.drug
musculoskeletal diseases
medicine.medical_specialty
Ovalbumin
Immune Cells
Immunology
Hypergravity
03 medical and health sciences
Signs and Symptoms
Diagnostic Medicine
Internal medicine
Genetics
medicine
Animals
Secretion
Asthma
Inflammation
Blood Cells
Superoxide Dismutase
business.industry
lcsh:R
Therapeutic effect
Biology and Life Sciences
Cell Biology
Molecular Development
medicine.disease
Rhinitis, Allergic
Eosinophils
030104 developmental biology
Endocrinology
Immune System
biology.protein
lcsh:Q
Nasal administration
Physiological Processes
business
Developmental Biology
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- PLOS ONE
- Accession number :
- edsair.doi.dedup.....90b099f6e68df3e81279799c6a400a16