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Primary Prophylaxis of Disseminated Histoplasmosis in HIV Patients in French Guiana: Arguments for Cost Effectiveness
- Source :
- American Journal of Tropical Medicine and Hygiene, American Journal of Tropical Medicine and Hygiene, American Society of Tropical Medicine and Hygiene, 2013, 89 (6), pp.1195-8. ⟨10.4269/ajtmh.13-0082⟩
- Publication Year :
- 2013
- Publisher :
- The American Society of Tropical Medicine and Hygiene, 2013.
-
Abstract
- International audience; Histoplasmosis is the first cause of acquired immunodeficiency syndrome (AIDS) and AIDS-related deaths in French Guiana. Cohort data were used to determine whether primary prophylaxis with 100 mg itraconazole for patients with CD4 counts < 150/mm(3) was cost-effective with different scenarios. For a scenario where 12% of patients died, 60% were aware of their human immunodeficiency virus (HIV) infection and adherence was only 50%, primary prophylaxis would prevent 1 death and 9 cases of histoplasmosis for a cost of 36,792 Euros per averted death, 1,533 per life-year saved, 4,415 Euros per averted case, when only counting the costs of itraconazole prophylaxis. Taking into account the total costs of hospitalization showed that primary prophylaxis would allow a savings of 185,178 Euros per year. Even in a scenario of low adherence, primary prophylaxis would be cost-effective in French Guiana, and presumably in the rest of the Guianas and the Amazon.
- Subjects :
- Male
Pediatrics
Antifungal Agents
Cost effectiveness
Cost-Benefit Analysis
HIV Infections
MESH: Hospitalization
Cohort Studies
0302 clinical medicine
MESH: Immunocompromised Host
MESH: Histoplasmosis
MESH: Incidence
MESH: Cohort Studies
Histoplasmosis
health care economics and organizations
0303 health sciences
biology
MESH: AIDS-Related Opportunistic Infections
Incidence
MESH: HIV Infections
Articles
3. Good health
French Guiana
Hospitalization
Infectious Diseases
Cohort
Female
Itraconazole
medicine.drug
medicine.medical_specialty
030231 tropical medicine
03 medical and health sciences
Immunocompromised Host
Acquired immunodeficiency syndrome (AIDS)
Disseminated histoplasmosis
Virology
MESH: French Guiana
parasitic diseases
medicine
Humans
MESH: Humans
AIDS-Related Opportunistic Infections
030306 microbiology
business.industry
Euros
MESH: Antifungal Agents
medicine.disease
biology.organism_classification
MESH: Male
Surgery
[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie
Hiv patients
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Parasitology
business
MESH: Itraconazole
MESH: Female
MESH: Cost-Benefit Analysis
Subjects
Details
- Language :
- English
- ISSN :
- 00029637
- Database :
- OpenAIRE
- Journal :
- American Journal of Tropical Medicine and Hygiene, American Journal of Tropical Medicine and Hygiene, American Society of Tropical Medicine and Hygiene, 2013, 89 (6), pp.1195-8. ⟨10.4269/ajtmh.13-0082⟩
- Accession number :
- edsair.doi.dedup.....90aedf616fdf6e067cb1258289c0566b